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N4BP2L2 NEDD4 binding protein 2 like 2 [ Homo sapiens (human) ]

Gene ID: 10443, updated on 16-Jun-2021

Summary

Official Symbol
N4BP2L2provided by HGNC
Official Full Name
NEDD4 binding protein 2 like 2provided by HGNC
Primary source
HGNC:HGNC:26916
See related
Ensembl:ENSG00000244754 MIM:615788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG005; CG016; PFAAP5; 92M18.3
Expression
Ubiquitous expression in thyroid (RPKM 5.4), ovary (RPKM 5.3) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See N4BP2L2 in Genome Data Viewer
Location:
13q13.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (32432485..32542710, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (33006622..33113022, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene BRCA2 DNA repair associated Neighboring gene interferon induced protein with tetratricopeptide repeats 1 pseudogene 1 Neighboring gene NEDD4 binding protein 2 like 1 Neighboring gene ATPase phospholipid transporting 8A2 pseudogene 2 Neighboring gene N4BPL2 intronic transcript 2 Neighboring gene MICOS10 pseudogene 1 Neighboring gene PDS5B divergent transcript Neighboring gene PDS5 cohesin associated factor B Neighboring gene RNY1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36195, FLJ41089, FLJ43077, DKFZp451G1516

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NEDD4-binding protein 2-like 2
Names
phosphonoformate immuno-associated protein 5
protein from BRCA2 region

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278432.2NP_001265361.1  NEDD4-binding protein 2-like 2 isoform 3

    See identical proteins and their annotated locations for NP_001265361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains an alternate exon in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL137247, AL353665
    Consensus CDS
    CCDS61307.1
    UniProtKB/TrEMBL
    B4DPY1
    Related
    ENSP00000350104.6, ENST00000357505.10
    Conserved Domains (1) summary
    pfam13671
    Location:1792
    AAA_33; AAA domain
  2. NM_001320836.3NP_001307765.1  NEDD4-binding protein 2-like 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses two alternate splice sites in the 5' coding region compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  3. NM_001387001.1NP_001373930.1  NEDD4-binding protein 2-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  4. NM_001387002.1NP_001373931.1  NEDD4-binding protein 2-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  5. NM_001387004.1NP_001373933.1  NEDD4-binding protein 2-like 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404421
    AAA_33; AAA domain
  6. NM_001387005.1NP_001373934.1  NEDD4-binding protein 2-like 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404433
    AAA_33; AAA domain
  7. NM_001387006.1NP_001373935.1  NEDD4-binding protein 2-like 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404433
    AAA_33; AAA domain
  8. NM_001387008.1NP_001373937.1  NEDD4-binding protein 2-like 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:10123
    AAA_33; AAA domain
  9. NM_001387009.1NP_001373938.1  NEDD4-binding protein 2-like 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:10123
    AAA_33; AAA domain
  10. NM_001387015.1NP_001373944.1  NEDD4-binding protein 2-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Related
    ENSP00000427477.1, ENST00000504114.5
    Conserved Domains (1) summary
    pfam13671
    Location:1792
    AAA_33; AAA domain
  11. NM_001387016.1NP_001373945.1  NEDD4-binding protein 2-like 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Related
    ENSP00000501483.1, ENST00000674456.1
  12. NM_001387017.1NP_001373946.1  NEDD4-binding protein 2-like 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404421
    AAA_33; AAA domain
  13. NM_001387018.1NP_001373947.1  NEDD4-binding protein 2-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:1792
    AAA_33; AAA domain
  14. NM_001387019.1NP_001373948.1  NEDD4-binding protein 2-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:1792
    AAA_33; AAA domain
  15. NM_001387020.1NP_001373949.1  NEDD4-binding protein 2-like 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  16. NM_001387059.1NP_001373988.1  NEDD4-binding protein 2-like 2 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:29105
    AAA_33; AAA domain
  17. NM_001387060.1NP_001373989.1  NEDD4-binding protein 2-like 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404421
    AAA_33; AAA domain
  18. NM_001387079.1NP_001374008.1  NEDD4-binding protein 2-like 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404421
    AAA_33; AAA domain
  19. NM_001387080.1NP_001374009.1  NEDD4-binding protein 2-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Related
    ENSP00000501416.1, ENST00000674465.1
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  20. NM_001387081.1NP_001374010.1  NEDD4-binding protein 2-like 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Related
    ENSP00000501533.1, ENST00000674428.1
    Conserved Domains (1) summary
    pfam13671
    Location:29148
    AAA_33; AAA domain
  21. NM_001387082.1NP_001374011.1  NEDD4-binding protein 2-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Related
    ENSP00000501516.1, ENST00000674349.1
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  22. NM_001387083.1NP_001374012.1  NEDD4-binding protein 2-like 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:10123
    AAA_33; AAA domain
  23. NM_001387099.1NP_001374028.1  NEDD4-binding protein 2-like 2 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:1792
    AAA_33; AAA domain
  24. NM_001387100.1NP_001374029.1  NEDD4-binding protein 2-like 2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:10122
    AAA_33; AAA domain
  25. NM_001387101.1NP_001374030.1  NEDD4-binding protein 2-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Related
    ENSP00000501518.1, ENST00000674421.1
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  26. NM_001387102.1NP_001374031.1  NEDD4-binding protein 2-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Related
    ENSP00000501537.1, ENST00000674484.1
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  27. NM_001387103.1NP_001374032.1  NEDD4-binding protein 2-like 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404535
    AAA_33; AAA domain
  28. NM_001387104.1NP_001374033.1  NEDD4-binding protein 2-like 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Related
    ENSP00000501454.1, ENST00000674327.1
    Conserved Domains (1) summary
    pfam13671
    Location:404467
    AAA_33; AAA domain
  29. NM_001387105.1NP_001374034.1  NEDD4-binding protein 2-like 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Related
    ENSP00000501387.1, ENST00000674377.1
    Conserved Domains (1) summary
    pfam13671
    Location:404421
    AAA_33; AAA domain
  30. NM_001387106.1NP_001374035.1  NEDD4-binding protein 2-like 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404421
    AAA_33; AAA domain
  31. NM_001387107.1NP_001374036.1  NEDD4-binding protein 2-like 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404438
    AAA_33; AAA domain
  32. NM_001387108.1NP_001374037.1  NEDD4-binding protein 2-like 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:404438
    AAA_33; AAA domain
  33. NM_001387165.1NP_001374094.1  NEDD4-binding protein 2-like 2 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:32107
    AAA_33; AAA domain
  34. NM_001387223.1NP_001374152.1  NEDD4-binding protein 2-like 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Related
    ENSP00000501321.1, ENST00000674180.1
    Conserved Domains (1) summary
    pfam13671
    Location:10123
    AAA_33; AAA domain
  35. NM_001387224.1NP_001374153.1  NEDD4-binding protein 2-like 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:29148
    AAA_33; AAA domain
  36. NM_001387225.1NP_001374154.1  NEDD4-binding protein 2-like 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL353665
    Conserved Domains (1) summary
    pfam13671
    Location:76208
    AAA_33; AAA domain
  37. NM_001395224.1NP_001382153.1  NEDD4-binding protein 2-like 2 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AL353665
  38. NM_014887.3NP_055702.1  NEDD4-binding protein 2-like 2 isoform 2

    See identical proteins and their annotated locations for NP_055702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses two alternate splice sites in the 5' coding region, and lacks multiple 3' exons, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL049783, AL353665, BG435390, CB217966
    Consensus CDS
    CCDS9346.1
    UniProtKB/Swiss-Prot
    Q92802
    UniProtKB/TrEMBL
    A0A024RDV2
    Related
    ENSP00000267068.3, ENST00000267068.5
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  39. NM_033111.5NP_149102.3  NEDD4-binding protein 2-like 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL137247, AL353665
    Consensus CDS
    CCDS45024.1
    UniProtKB/TrEMBL
    Q9Y3H6
    Related
    ENSP00000382328.3, ENST00000399396.7
    Conserved Domains (1) summary
    pfam13671
    Location:32107
    AAA_33; AAA domain

RNA

  1. NR_170379.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  2. NR_170380.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  3. NR_170381.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  4. NR_170382.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  5. NR_170383.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  6. NR_170384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  7. NR_170385.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  8. NR_170386.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  9. NR_170387.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  10. NR_170388.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  11. NR_170389.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  12. NR_170390.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL137247, AL353665
  13. NR_170544.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  14. NR_170545.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  15. NR_170546.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  16. NR_170547.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  17. NR_170548.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  18. NR_170549.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  19. NR_170551.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  20. NR_170552.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  21. NR_170554.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  22. NR_170555.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  23. NR_170556.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  24. NR_170557.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665
  25. NR_170558.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL353665

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    32432485..32542710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534871.2XP_011533173.1  NEDD4-binding protein 2-like 2 isoform X8

    See identical proteins and their annotated locations for XP_011533173.1

  2. XM_011534872.3XP_011533174.1  NEDD4-binding protein 2-like 2 isoform X10

    See identical proteins and their annotated locations for XP_011533174.1

    UniProtKB/TrEMBL
    Q9Y3H6
    Related
    ENST00000380121.7
  3. XM_017020328.2XP_016875817.1  NEDD4-binding protein 2-like 2 isoform X2

    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  4. XM_017020326.1XP_016875815.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  5. XM_017020332.1XP_016875821.1  NEDD4-binding protein 2-like 2 isoform X3

  6. XM_024449307.1XP_024305075.1  NEDD4-binding protein 2-like 2 isoform X5

    Conserved Domains (1) summary
    cl26098
    Location:1792
    AAA_33; AAA domain
  7. XM_024449306.1XP_024305074.1  NEDD4-binding protein 2-like 2 isoform X5

    Conserved Domains (1) summary
    cl26098
    Location:1792
    AAA_33; AAA domain
  8. XM_017020331.1XP_016875820.1  NEDD4-binding protein 2-like 2 isoform X3

  9. XM_017020327.1XP_016875816.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  10. XM_024449309.1XP_024305077.1  NEDD4-binding protein 2-like 2 isoform X5

    Conserved Domains (1) summary
    cl26098
    Location:1792
    AAA_33; AAA domain
  11. XM_017020324.2XP_016875813.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  12. XM_017020325.2XP_016875814.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  13. XM_024449305.1XP_024305073.1  NEDD4-binding protein 2-like 2 isoform X1

    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
  14. XM_024449310.1XP_024305078.1  NEDD4-binding protein 2-like 2 isoform X5

    Conserved Domains (1) summary
    cl26098
    Location:1792
    AAA_33; AAA domain
  15. XM_024449312.1XP_024305080.1  NEDD4-binding protein 2-like 2 isoform X11

  16. XM_024449313.1XP_024305081.1  NEDD4-binding protein 2-like 2 isoform X11

  17. XM_017020346.1XP_016875835.1  NEDD4-binding protein 2-like 2 isoform X11

    Related
    ENST00000503296.6
  18. XM_017020337.1XP_016875826.1  NEDD4-binding protein 2-like 2 isoform X7

  19. XM_017020338.1XP_016875827.1  NEDD4-binding protein 2-like 2 isoform X7

  20. XM_017020344.1XP_016875833.1  NEDD4-binding protein 2-like 2 isoform X11

  21. XM_017020343.1XP_016875832.1  NEDD4-binding protein 2-like 2 isoform X11

  22. XM_017020345.1XP_016875834.1  NEDD4-binding protein 2-like 2 isoform X11

  23. XM_017020340.1XP_016875829.1  NEDD4-binding protein 2-like 2 isoform X9

  24. XM_017020339.1XP_016875828.1  NEDD4-binding protein 2-like 2 isoform X9

  25. XM_017020341.1XP_016875830.1  NEDD4-binding protein 2-like 2 isoform X9

  26. XM_011534874.3XP_011533176.1  NEDD4-binding protein 2-like 2 isoform X13

    Conserved Domains (2) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
    cl17190
    Location:404534
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  27. XM_017020349.1XP_016875838.1  NEDD4-binding protein 2-like 2 isoform X12

    UniProtKB/Swiss-Prot
    Q92802
    UniProtKB/TrEMBL
    A0A024RDV2
    Conserved Domains (1) summary
    pfam13671
    Location:404536
    AAA_33; AAA domain
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