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RBM14 RNA binding motif protein 14 [ Homo sapiens (human) ]

Gene ID: 10432, updated on 11-Sep-2019

Summary

Official Symbol
RBM14provided by HGNC
Official Full Name
RNA binding motif protein 14provided by HGNC
Primary source
HGNC:HGNC:14219
See related
Ensembl:ENSG00000239306 MIM:612409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; COAA; PSP2; SYTIP1; TMEM137
Summary
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
Annotation information
Note: The nomenclature TMEM137, transmembrane protein 137 was assigned to BC024260, which is now thought to represent the 3' UTR of RBM14. [15 Aug 2008]
Expression
Ubiquitous expression in testis (RPKM 11.0), lymph node (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See RBM14 in Genome Data Viewer
Location:
11q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66616630..66629934)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66384053..66397405)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene copper chaperone for superoxide dismutase Neighboring gene RBM14-RBM4 readthrough Neighboring gene RNA, U4 small nuclear 39, pseudogene Neighboring gene RNA binding motif protein 4 Neighboring gene RNA binding motif protein 4B Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene RNA, 7SL, cytoplasmic 12, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev The localization of RBM14 to the nuclear paraspeckles is required for RBM14 enhancement of HIV-1 Rev activity in cells PubMed
rev Co-immunoprecipitation analysis demonstrates that endogenous RBM14 associates with HIV-1 Rev, XPO1, and p54/NRB in cells PubMed
rev Depletion of RBM14 inhibits HIV-1 Rev activity, leading to reduced HIV-1 p24 expression from the Rev-mediated reporter plasmid PubMed
Tat tat RNA binding motif protein 14 (RBM14) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
capsid gag Depletion of RBM14 inhibits HIV-1 Rev activity, leading to reduced HIV-1 p24 expression from the Rev-mediated reporter plasmid PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough RBM14-RBM4

Readthrough gene: RBM14-RBM4, Included gene: RBM4

Homology

Clone Names

  • MGC15912, MGC31756, DKFZp779J0927

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging NAS
Non-traceable Author Statement
more info
PubMed 
transcription coregulator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA recombination NAS
Non-traceable Author Statement
more info
PubMed 
DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
centriole assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucocorticoid receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
histone deacetylation IPI
Inferred from Physical Interaction
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
intracellular estrogen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
response to hormone TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mediator complex NAS
Non-traceable Author Statement
more info
PubMed 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex TAS
Traceable Author Statement
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 14
Names
RRM-containing coactivator activator/modulator
SYT-interacting protein
paraspeckle protein 2
synaptotagmin-interacting protein
transmembrane protein 137

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030394.1 RefSeqGene

    Range
    5049..18353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198836.2NP_001185765.1  RNA-binding protein 14 isoform 2

    See identical proteins and their annotated locations for NP_001185765.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (2, also known as CoAM or coactivator modulator) with a distinct and shorter C-terminus compared to isoform 1. This isoform lacks the TRBP-interacting domain, and functions as a transcriptional repressor by inhibiting the activity of isoform 1 (PMID:11443112).
    Source sequence(s)
    AF315633, AP001157
    Consensus CDS
    CCDS55772.1
    UniProtKB/Swiss-Prot
    Q96PK6
    UniProtKB/TrEMBL
    A0A0S2Z567
    Related
    ENSP00000377548.3, ENST00000393979.3
    Conserved Domains (2) summary
    cd12609
    Location:79146
    RRM2_CoAA; RNA recognition motif 2 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cl17169
    Location:171
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001198837.2NP_001185766.1  RNA-binding protein 14 isoform 3

    See identical proteins and their annotated locations for NP_001185766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (3, also known as CoAR or coactivator regulator) with a distinct and shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AP001157, DB044990, DQ294957
    Consensus CDS
    CCDS55773.1
    UniProtKB/Swiss-Prot
    Q96PK6
    UniProtKB/TrEMBL
    A0A0S2Z5V2
    Related
    ENSP00000386995.4, ENST00000409738.4
    Conserved Domains (1) summary
    cl17169
    Location:171
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_006328.4NP_006319.1  RNA-binding protein 14 isoform 1

    See identical proteins and their annotated locations for NP_006319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CoAA or coactivator activator).
    Source sequence(s)
    AK021768, AP001157, DB044990
    Consensus CDS
    CCDS8147.1
    UniProtKB/Swiss-Prot
    Q96PK6
    UniProtKB/TrEMBL
    A0A0S2Z4Z0
    Related
    ENSP00000311747.4, ENST00000310137.4
    Conserved Domains (4) summary
    PRK13875
    Location:319433
    PRK13875; conjugal transfer protein TrbL; Provisional
    cd12608
    Location:171
    RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cd12609
    Location:79146
    RRM2_CoAA; RNA recognition motif 2 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cl25887
    Location:3280
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66616630..66629934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032886.2: Suppressed sequence

    Description
    NM_032886.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Support Center