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Csnk1d casein kinase 1, delta [ Mus musculus (house mouse) ]

Gene ID: 104318, updated on 21-Dec-2022

Summary

Official Symbol
Csnk1dprovided by MGI
Official Full Name
casein kinase 1, deltaprovided by MGI
Primary source
MGI:MGI:1355272
See related
Ensembl:ENSMUSG00000025162 AllianceGenome:MGI:1355272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200006A05Rik; D930010H05Rik
Summary
This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E14 (RPKM 50.8), whole brain E14.5 (RPKM 50.5) and 28 other tissues See more
Orthologs
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Genomic context

See Csnk1d in Genome Data Viewer
Location:
11; 11 E2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120848535..120882180, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120957709..120991350, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene fatty acid synthase Neighboring gene coiled-coil domain containing 57 Neighboring gene RIKEN cDNA A430102A20 gene Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 3 Neighboring gene predicted gene, 53204 Neighboring gene predicted gene, 30062

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of non-canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
casein kinase I isoform delta; casein kinase I
Names
CKI-delta
CKId
tau-protein kinase CSNK1D
NP_082150.1
NP_620690.1
XP_011246964.1
XP_011246965.1
XP_036012094.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027874.3NP_082150.1  casein kinase I isoform delta isoform 2

    See identical proteins and their annotated locations for NP_082150.1

    Status: VALIDATED

    Source sequence(s)
    AL662887, AL662901
    Consensus CDS
    CCDS25763.1
    UniProtKB/TrEMBL
    A0A6P5QS33, A0A8C6GZ24, Q3UBT6
    Related
    ENSMUSP00000070721.8, ENSMUST00000070575.14
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. NM_139059.3NP_620690.1  casein kinase I isoform delta isoform 1

    See identical proteins and their annotated locations for NP_620690.1

    Status: VALIDATED

    Source sequence(s)
    AL662887, AL662901
    Consensus CDS
    CCDS25762.1
    UniProtKB/Swiss-Prot
    Q9DC28
    UniProtKB/TrEMBL
    A0A6P5QTU6, A0A8C6H0J7
    Related
    ENSMUSP00000018274.4, ENSMUST00000018274.10
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120848535..120882180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248663.4XP_011246965.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011246965.1

    UniProtKB/TrEMBL
    A0A6P5QXG7, A0A8C6GZN8, Q3USK2
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. XM_011248662.3XP_011246964.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011246964.1

    UniProtKB/TrEMBL
    A0A6P5QXG7, A0A8C6GZN8, Q3USK2
    Related
    ENSMUSP00000158953.2, ENSMUST00000239115.2
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  3. XM_036156201.1XP_036012094.1  casein kinase I isoform X2

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon