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PGRMC2 progesterone receptor membrane component 2 [ Homo sapiens (human) ]

Gene ID: 10424, updated on 7-Jun-2020

Summary

Official Symbol
PGRMC2provided by HGNC
Official Full Name
progesterone receptor membrane component 2provided by HGNC
Primary source
HGNC:HGNC:16089
See related
Ensembl:ENSG00000164040 MIM:607735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DG6; PMBP
Expression
Ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues See more
Orthologs

Genomic context

See PGRMC2 in Genome Data Viewer
Location:
4q28.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (128269242..128288205, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (129190392..129209984, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 1B Neighboring gene ribosomal protein L15 pseudogene 8 Neighboring gene FOSL1 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 2615 Neighboring gene NFE2L2 motif-containing MPRA enhancer 199 Neighboring gene uncharacterized LOC101927259

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of progesterone receptor membrane component 2 (PGRMC2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of progesterone receptor membrane component 2 (PGRMC2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
heme transporter activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
steroid hormone receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heme transport IEA
Inferred from Electronic Annotation
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
membrane-associated progesterone receptor component 2
Names
progesterone membrane binding protein
steroid receptor protein DG6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006320.6NP_006311.3  membrane-associated progesterone receptor component 2

    Status: VALIDATED

    Source sequence(s)
    AI375856, AK091741, AK131272
    Consensus CDS
    CCDS3739.2
    Related
    ENSP00000296425.4, ENST00000296425.10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    128269242..128288205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531533.2XP_011529835.1  membrane-associated progesterone receptor component 2 isoform X1

    Conserved Domains (1) summary
    cl02041
    Location:126161
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
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