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CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase [ Homo sapiens (human) ]

Gene ID: 10423, updated on 3-May-2020

Summary

Official Symbol
CDIPTprovided by HGNC
Official Full Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:1769
See related
Ensembl:ENSG00000103502 MIM:605893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIS; PIS1
Summary
Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in ovary (RPKM 31.5), fat (RPKM 28.7) and 25 other tissues See more
Orthologs

Genomic context

See CDIPT in Genome Data Viewer
Location:
16p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (29858357..29863226, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29869678..29874801, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene proline rich transmembrane protein 2 Neighboring gene PAXIP1 associated glutamate rich protein 1 Neighboring gene major vault protein Neighboring gene CDIP transferase opposite strand, pseudogene Neighboring gene seizure related 6 homolog like 2 Neighboring gene Sharpr-MPRA regulatory region 6067

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1328

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
alcohol binding IEA
Inferred from Electronic Annotation
more info
 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CDP-diacylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Names
PI synthase
PtdIns synthase
phosphatidylinositol synthase
NP_001273514.1
NP_001273515.1
NP_006310.1
XP_005255095.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286585.2NP_001273514.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI696848, AK097691, AK300805
    Consensus CDS
    CCDS67002.1
    UniProtKB/Swiss-Prot
    O14735
    UniProtKB/TrEMBL
    A8K3L7
    Related
    ENSP00000457340.1, ENST00000566113.5
  2. NM_001286586.2NP_001273515.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3

    See identical proteins and their annotated locations for NP_001273515.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AI696848, AK097691, BX333193
    UniProtKB/TrEMBL
    A8K3L7
  3. NM_006319.5NP_006310.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1

    See identical proteins and their annotated locations for NP_006310.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI696848, AK097691
    Consensus CDS
    CCDS10657.1
    UniProtKB/Swiss-Prot
    O14735
    UniProtKB/TrEMBL
    A8K3L7
    Related
    ENSP00000219789.6, ENST00000219789.11
    Conserved Domains (1) summary
    pfam01066
    Location:1072
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    29858357..29863226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255038.4XP_005255095.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1

    See identical proteins and their annotated locations for XP_005255095.1

    UniProtKB/TrEMBL
    B3KY94
    Related
    ENSP00000455042.1, ENST00000561555.5
    Conserved Domains (1) summary
    cl00453
    Location:85223
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145752.1: Suppressed sequence

    Description
    NM_145752.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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