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UBAC1 UBA domain containing 1 [ Homo sapiens (human) ]

Gene ID: 10422, updated on 6-Sep-2022

Summary

Official Symbol
UBAC1provided by HGNC
Official Full Name
UBA domain containing 1provided by HGNC
Primary source
HGNC:HGNC:30221
See related
Ensembl:ENSG00000130560 MIM:608129; AllianceGenome:HGNC:30221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KPC2; GBDR1; UBADC1
Summary
Predicted to be involved in protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 32.5), testis (RPKM 24.1) and 25 other tissues See more
Orthologs
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Genomic context

See UBAC1 in Genome Data Viewer
Location:
9q34.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (135932969..135961373, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (148160391..148188795, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138824815..138853219, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 8889 Neighboring gene CAMSAP1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 7357 Neighboring gene uncharacterized LOC124902307 Neighboring gene NACC family member 2 Neighboring gene uncharacterized LOC107987142 Neighboring gene transmembrane protein 250

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-associated domain-containing protein 1
Names
E3 ubiquitin-protein ligase subunit KPC2
Kip1 ubiquitination-promoting complex subunit 2
UBA domain-containing protein 1
glialblastoma cell differentiation-related protein 1
kip1 ubiquitination-promoting complex protein 2
putative glialblastoma cell differentiation-related protein
testicular secretory protein Li 64
ubiquitin associated domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016172.3NP_057256.2  ubiquitin-associated domain-containing protein 1

    See identical proteins and their annotated locations for NP_057256.2

    Status: VALIDATED

    Source sequence(s)
    AL355574
    Consensus CDS
    CCDS35177.1
    UniProtKB/Swiss-Prot
    Q9BSL1, Q9UMW7
    UniProtKB/TrEMBL
    A0A140VK64
    Related
    ENSP00000360821.3, ENST00000371756.4
    Conserved Domains (3) summary
    smart00727
    Location:353392
    STI1; Heat shock chaperonin-binding motif
    cd14303
    Location:195232
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd14304
    Location:290327
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    135932969..135961373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    148160391..148188795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)