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CD2BP2 CD2 cytoplasmic tail binding protein 2 [ Homo sapiens (human) ]

Gene ID: 10421, updated on 4-Oct-2020

Summary

Official Symbol
CD2BP2provided by HGNC
Official Full Name
CD2 cytoplasmic tail binding protein 2provided by HGNC
Primary source
HGNC:HGNC:1656
See related
Ensembl:ENSG00000169217 MIM:604470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIN1; Snu40; FWP010; U5-52K; PPP1R59
Summary
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in brain (RPKM 16.4), lymph node (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See CD2BP2 in Genome Data Viewer
Location:
16p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30350773..30355308, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30362087..30366682, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SMG1 pseudogene 5 Neighboring gene carbonic anhydrase 5A pseudogene Neighboring gene Sharpr-MPRA regulatory region 48 Neighboring gene CD2BP2 divergent transcript Neighboring gene TBC1 domain family member 10B Neighboring gene Sharpr-MPRA regulatory region 9884 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal tri-snRNP complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
NOT U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U5 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
colocalizes_with nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CD2 antigen cytoplasmic tail-binding protein 2
Names
CD2 cytoplasmic domain-binding protein 2
U5 snRNP 52K protein
protein phosphatase 1, regulatory subunit 59

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243646.2NP_001230575.1  CD2 antigen cytoplasmic tail-binding protein 2

    See identical proteins and their annotated locations for NP_001230575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB033004, BC013854
    Consensus CDS
    CCDS10675.1
    UniProtKB/Swiss-Prot
    O95400
    UniProtKB/TrEMBL
    A0A024QZC1
    Related
    ENSP00000456935.1, ENST00000569466.1
    Conserved Domains (1) summary
    cd00072
    Location:280340
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
  2. NM_006110.3NP_006101.1  CD2 antigen cytoplasmic tail-binding protein 2

    See identical proteins and their annotated locations for NP_006101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter and more abundant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB033004, BC001947, CB135964
    Consensus CDS
    CCDS10675.1
    UniProtKB/Swiss-Prot
    O95400
    UniProtKB/TrEMBL
    A0A024QZC1
    Related
    ENSP00000304903.3, ENST00000305596.8
    Conserved Domains (1) summary
    cd00072
    Location:280340
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30350773..30355308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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