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Blmh bleomycin hydrolase [ Mus musculus (house mouse) ]

Gene ID: 104184, updated on 9-May-2024

Summary

Official Symbol
Blmhprovided by MGI
Official Full Name
bleomycin hydrolaseprovided by MGI
Primary source
MGI:MGI:1345186
See related
Ensembl:ENSMUSG00000020840 AllianceGenome:MGI:1345186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bh; Bmh
Summary
The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 34.4), CNS E14 (RPKM 21.5) and 25 other tissues See more
Orthologs
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Genomic context

See Blmh in Genome Data Viewer
Location:
11 B5; 11 46.16 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76836482..76878215)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76945656..76987389)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40200 Neighboring gene transmembrane and immunoglobulin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_30046 Neighboring gene STARR-positive B cell enhancer mm9_chr11:76759053-76759354 Neighboring gene STARR-seq mESC enhancer starr_30047 Neighboring gene solute carrier family 6 member 4 gene promoter Neighboring gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Neighboring gene predicted gene 12343 Neighboring gene nuclear speckle regulatory protein 1 Neighboring gene predicted gene, 22772

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC36899, MGC37104, MGC39026

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in homocysteine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bleomycin hydrolase
Names
BLM hydrolase
NP_848760.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178645.4NP_848760.1  bleomycin hydrolase

    See identical proteins and their annotated locations for NP_848760.1

    Status: REVIEWED

    Source sequence(s)
    AK049461, BY087076, BY643607
    Consensus CDS
    CCDS25073.1
    UniProtKB/Swiss-Prot
    Q3TJR8, Q8BLZ4, Q8BZH9, Q8C111, Q8CID9, Q8R016
    Related
    ENSMUSP00000021197.4, ENSMUST00000021197.10
    Conserved Domains (1) summary
    pfam03051
    Location:5451
    Peptidase_C1_2; Peptidase C1-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76836482..76878215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)