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SPON2 spondin 2 [ Homo sapiens (human) ]

Gene ID: 10417, updated on 28-Nov-2021

Summary

Official Symbol
SPON2provided by HGNC
Official Full Name
spondin 2provided by HGNC
Primary source
HGNC:HGNC:11253
See related
Ensembl:ENSG00000159674 MIM:605918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIL1; DIL-1; MINDIN; M-SPONDIN
Expression
Broad expression in prostate (RPKM 48.4), endometrium (RPKM 37.2) and 18 other tissues See more
Orthologs
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Genomic context

See SPON2 in Genome Data Viewer
Location:
4p16.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (1166932..1208844, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1160720..1202632, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 212 Neighboring gene protein phosphatase 2 regulatory subunit B, alpha pseudogene Neighboring gene uncharacterized LOC105374344 Neighboring gene transmembrane p24 trafficking protein 11, pseudogene Neighboring gene uncharacterized LOC100130872 Neighboring gene CTBP1 antisense RNA Neighboring gene C-terminal binding protein 1 Neighboring gene CTBP1 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Sequence variants in the RNF212 gene associate with genome-wide recombination rate.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16313, FLJ22401, FLJ34460, DKFZp686G21139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IEA
Inferred from Electronic Annotation
more info
 
enables lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in induction of bacterial agglutination IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mast cell mediated immunity IEA
Inferred from Electronic Annotation
more info
 
involved_in opsonization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
spondin-2
Names
differentially expressed in cancerous and non-cancerous lung cells 1
spondin 2, extracellular matrix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128325.3NP_001121797.2  spondin-2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS3347.1
    Related
    ENSP00000394832.1, ENST00000431380.5
    Conserved Domains (2) summary
    pfam06468
    Location:41228
    Spond_N; Spondin_N
    pfam19028
    Location:278330
    TSP1_spondin; Spondin-like TSP1 domain
  2. NM_001199021.2NP_001185950.2  spondin-2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. It also represents a read-through transcript because it shares its first exon with that of the upstream, non-coding gene (GeneID:100130872). Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS3347.1
    Related
    ENSP00000483599.1, ENST00000617421.4
    Conserved Domains (2) summary
    pfam06468
    Location:41228
    Spond_N; Spondin_N
    pfam19028
    Location:278330
    TSP1_spondin; Spondin-like TSP1 domain
  3. NM_012445.4NP_036577.2  spondin-2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2 and 3.
    Source sequence(s)
    AC092535
    Consensus CDS
    CCDS3347.1
    Related
    ENSP00000290902.5, ENST00000290902.10
    Conserved Domains (2) summary
    pfam06468
    Location:41228
    Spond_N; Spondin_N
    pfam19028
    Location:278330
    TSP1_spondin; Spondin-like TSP1 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    1166932..1208844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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