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Adcy4 adenylate cyclase 4 [ Mus musculus (house mouse) ]

Gene ID: 104110, updated on 29-Oct-2021

Summary

Official Symbol
Adcy4provided by MGI
Official Full Name
adenylate cyclase 4provided by MGI
Primary source
MGI:MGI:99674
See related
Ensembl:ENSMUSG00000022220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4004
Expression
Biased expression in lung adult (RPKM 35.4), subcutaneous fat pad adult (RPKM 10.2) and 10 other tissues See more
Orthologs
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Genomic context

See Adcy4 in Genome Data Viewer
Location:
14; 14 C3
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56006513..56021552, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55769056..55784095, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56387929..56402856, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor 1 Neighboring gene predicted gene, 32092 Neighboring gene receptor-interacting serine-threonine kinase 3 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4004

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G-protein beta/gamma-subunit complex binding ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenylate cyclase type 4
Names
ATP pyrophosphate-lyase 4
adenylate cyclase type IV
adenylyl cyclase 4
NP_001348533.1
NP_536683.1
XP_006518387.1
XP_006518388.1
XP_006518389.1
XP_036014230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361604.1NP_001348533.1  adenylate cyclase type 4

    Status: VALIDATED

    Source sequence(s)
    AC098877, AK141767, BY346402
    Consensus CDS
    CCDS27130.1
    Related
    ENSMUSP00000130530.2, ENSMUST00000170223.9
    Conserved Domains (3) summary
    pfam00211
    Location:8661065
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:115246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:479580
    DUF1053; Domain of Unknown Function (DUF1053)
  2. NM_080435.2NP_536683.1  adenylate cyclase type 4

    See identical proteins and their annotated locations for NP_536683.1

    Status: VALIDATED

    Source sequence(s)
    AC098877, AK141767, AK161880, BY346402
    Consensus CDS
    CCDS27130.1
    UniProtKB/Swiss-Prot
    Q91WF3
    Related
    ENSMUSP00000002398.8, ENSMUST00000002398.9
    Conserved Domains (3) summary
    pfam00211
    Location:8661065
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:115246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:479580
    DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56006513..56021552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518324.1XP_006518387.1  adenylate cyclase type 4 isoform X1

    See identical proteins and their annotated locations for XP_006518387.1

    UniProtKB/Swiss-Prot
    Q91WF3
    Conserved Domains (3) summary
    pfam00211
    Location:8661065
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:115246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:479580
    DUF1053; Domain of Unknown Function (DUF1053)
  2. XM_036158337.1XP_036014230.1  adenylate cyclase type 4 isoform X4

    Conserved Domains (3) summary
    pfam00211
    Location:525724
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:138239
    DUF1053; Domain of Unknown Function (DUF1053)
    cl11967
    Location:1577
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
  3. XM_006518326.3XP_006518389.1  adenylate cyclase type 4 isoform X3

    Conserved Domains (3) summary
    pfam00211
    Location:552751
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:165266
    DUF1053; Domain of Unknown Function (DUF1053)
    cl11967
    Location:2104
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
  4. XM_006518325.3XP_006518388.1  adenylate cyclase type 4 isoform X2

    Conserved Domains (4) summary
    pfam00211
    Location:264418
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:115246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:479580
    DUF1053; Domain of Unknown Function (DUF1053)
    cl11967
    Location:866939
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
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