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Itga9 integrin alpha 9 [ Mus musculus (house mouse) ]

Gene ID: 104099, updated on 8-Dec-2022

Summary

Official Symbol
Itga9provided by MGI
Official Full Name
integrin alpha 9provided by MGI
Primary source
MGI:MGI:104756
See related
Ensembl:ENSMUSG00000039115 AllianceGenome:MGI:104756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
(alpha)9; D130073C02; D9Ertd428e; 2610002H11Rik; 6720458D17Rik
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within neutrophil chemotaxis. Located in basal plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; skin; and vascular system. Used to study congenital chylothorax. Human ortholog(s) of this gene implicated in cerebral infarction; hypertension; and pancreatic cancer. Orthologous to human ITGA9 (integrin subunit alpha 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 10.7), ovary adult (RPKM 10.3) and 22 other tissues See more
Orthologs
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Genomic context

See Itga9 in Genome Data Viewer
Location:
9 F3; 9 70.32 cM
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118435777..118730071)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118606709..118901003)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33460 Neighboring gene golgi autoantigen, golgin subfamily a, 4 Neighboring gene family with sequence similarity 64, member A pseudogene Neighboring gene predicted gene 10157 Neighboring gene predicted gene, 39454 Neighboring gene uncharacterized LOC102636563 Neighboring gene predicted gene, 51695 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like Neighboring gene VISTA enhancer mm1627 Neighboring gene predicted gene, 53514

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables laminin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of integrin alpha9-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113514.1NP_001106986.1  integrin alpha-9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC156800, AK139690, CF913701
    Consensus CDS
    CCDS52961.1
    UniProtKB/TrEMBL
    E9QAP0, Q3UT74
    Related
    ENSMUSP00000122417.2, ENSMUST00000124360.8
    Conserved Domains (1) summary
    pfam08441
    Location:2318
    Integrin_alpha2; Integrin alpha
  2. NM_133721.2NP_598482.2  integrin alpha-9 isoform a precursor

    See identical proteins and their annotated locations for NP_598482.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC156800, AK153585, BB638856, CN698186
    Consensus CDS
    CCDS23604.1
    UniProtKB/Swiss-Prot
    B8JK39, B9EKC4
    Related
    ENSMUSP00000044227.8, ENSMUST00000044165.14
    Conserved Domains (2) summary
    smart00191
    Location:362415
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:460904
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    118435777..118730071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)