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BASP1 brain abundant membrane attached signal protein 1 [ Homo sapiens (human) ]

Gene ID: 10409, updated on 3-Jun-2018
Official Symbol
BASP1provided by HGNC
Official Full Name
brain abundant membrane attached signal protein 1provided by HGNC
Primary source
HGNC:HGNC:957
See related
Ensembl:ENSG00000176788 MIM:605940; Vega:OTTHUMG00000131061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP23; NAP22; CAP-23; NAP-22
Summary
This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]
Expression
Biased expression in brain (RPKM 144.2), prostate (RPKM 45.3) and 10 other tissues See more
Orthologs
See BASP1 in Genome Data Viewer
Location:
5p15.1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (17216823..17276845)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (17216932..17276954)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene BASP1 antisense RNA 1 Neighboring gene uncharacterized LOC105374664 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 2 Neighboring gene RNA, U6 small nuclear 1003, pseudogene Neighboring gene BASP1-FTH1P10 intergenic CAGE-defined low expression enhancer Neighboring gene aurora kinase A interacting protein 1 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of brain membrane attached signal protein 1 (BASP1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC8555

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
diaphragm development ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerular visceral epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
gonad development ISS
Inferred from Sequence or Structural Similarity
more info
 
mesenchymal to epithelial transition ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric mesenchyme development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of heart growth ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of metanephric ureteric bud development ISS
Inferred from Sequence or Structural Similarity
more info
 
substantia nigra development HEP PubMed 
thorax and anterior abdomen determination ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
vesicle HDA PubMed 
Preferred Names
brain acid soluble protein 1
Names
22 kDa neuronal tissue-enriched acidic protein
brain acid-soluble protein 1
neuronal axonal membrane protein NAP-22
neuronal tissue-enriched acidic protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271606.1NP_001258535.1  brain acid soluble protein 1

    See identical proteins and their annotated locations for NP_001258535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000518, BM973114, BU181147, DA489123, DW458407, HY258599
    Consensus CDS
    CCDS3888.1
    UniProtKB/Swiss-Prot
    P80723
    Related
    ENSP00000482066.1, ENST00000616743.1
    Conserved Domains (1) summary
    pfam05466
    Location:12227
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
  2. NM_006317.4NP_006308.3  brain acid soluble protein 1

    See identical proteins and their annotated locations for NP_006308.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000518, BM973114, BU181147, CN355202, HY258599
    Consensus CDS
    CCDS3888.1
    UniProtKB/Swiss-Prot
    P80723
    Related
    ENSP00000319281.3, OTTHUMP00000161694, ENST00000322611.3, OTTHUMT00000253716
    Conserved Domains (1) summary
    pfam05466
    Location:12227
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    17216823..17276845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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