Format

Send to:

Choose Destination

SPAG11B sperm associated antigen 11B [ Homo sapiens (human) ]

Gene ID: 10407, updated on 11-Jun-2021

Summary

Official Symbol
SPAG11Bprovided by HGNC
Official Full Name
sperm associated antigen 11Bprovided by HGNC
Primary source
HGNC:HGNC:14534
See related
Ensembl:ENSG00000164871 MIM:606560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP2; HE2; EP2C; EP2D; HE2C; EDDM2B; SPAG11; SPAG11A
Summary
This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SPAG11B in Genome Data Viewer
Location:
8p23.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (7447754..7463542, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7305276..7321196, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 3 Neighboring gene defensin beta 103B Neighboring gene defensin beta 104B Neighboring gene defensin beta 106B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC61846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
sperm-associated antigen 11B
Names
Protein EP2
Sperm-associated antigen 11A
epididymal protein 2B
human epididymis-specific protein 2
sperm antigen HE2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029571.1 RefSeqGene

    Range
    5001..20917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016512.5NP_057596.1  sperm-associated antigen 11B isoform A preproprotein

    See identical proteins and their annotated locations for NP_057596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) is also called the alpha1 transcript. It lacks two internal exons and encodes an isoform (A) whose C-terminus is identical to that of isoform B encoded by variant B.
    Source sequence(s)
    AC130360, AF168616
    Consensus CDS
    CCDS5966.1
    UniProtKB/Swiss-Prot
    Q08648
    Related
    ENSP00000297498.2, ENST00000297498.6
    Conserved Domains (1) summary
    pfam05324
    Location:871
    Sperm_Ag_HE2; Sperm antigen HE2
  2. NM_058200.4NP_478107.2  sperm-associated antigen 11B isoform G preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (G) is also called the beta2 transcript. It lacks four internal exons. The C-terminus of the resulting isoform (G) is identical to that of isoform H encoded by variant H.
    Source sequence(s)
    AA694479, AC130360, AF168617
    Consensus CDS
    CCDS5964.1
    UniProtKB/Swiss-Prot
    Q08648
    UniProtKB/TrEMBL
    A0A0A0MRG4
    Related
    ENSP00000352797.5, ENST00000359758.9
    Conserved Domains (1) summary
    pfam05324
    Location:872
    Sperm_Ag_HE2; Sperm antigen HE2
  3. NM_058201.4NP_478108.2  sperm-associated antigen 11B isoform D preproprotein

    See identical proteins and their annotated locations for NP_478108.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) is also called the beta1 transcript. It lacks three internal exons. The C-terminus of the encoded isoform (D) is identical to that of isoform E encoded by variant E. Isoform D has a region with similarity to beta-defensins.
    Source sequence(s)
    AC130360, AF168617
    Consensus CDS
    CCDS47774.1
    UniProtKB/Swiss-Prot
    Q08648
    Related
    ENSP00000381480.2, ENST00000398462.7
    Conserved Domains (2) summary
    pfam00711
    Location:80113
    Defensin_beta; Beta defensin
    pfam05324
    Location:872
    Sperm_Ag_HE2; Sperm antigen HE2
  4. NM_058202.4NP_478109.1  sperm-associated antigen 11B isoform H preproprotein

    See identical proteins and their annotated locations for NP_478109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (H) is also called the gamma1 transcript. It lacks five internal exons. The C-terminus of the resulting isoform (H) is identical to that of isoform G encoded by variant G.
    Source sequence(s)
    AC130360, AF168617
    Consensus CDS
    CCDS5965.1
    UniProtKB/Swiss-Prot
    Q08648, Q6PDA7
    Related
    ENSP00000354411.2, ENST00000361111.6
    Conserved Domains (1) summary
    pfam05324
    Location:874
    Sperm_Ag_HE2; Sperm antigen HE2
  5. NM_058203.4NP_478110.1  sperm-associated antigen 11B isoform C preproprotein

    See identical proteins and their annotated locations for NP_478110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) has an alternate 3' UTR, compared to variant A. The resulting isoform (C) has an unique C-terminus and a region with similarity to beta-defensins.
    Source sequence(s)
    AC130360, AF168616, AJ635328
    Consensus CDS
    CCDS5967.1
    UniProtKB/Swiss-Prot
    Q08648
    Related
    ENSP00000322591.5, ENST00000317900.7
    Conserved Domains (1) summary
    pfam05324
    Location:874
    Sperm_Ag_HE2; Sperm antigen HE2
  6. NM_058206.5NP_478113.2  sperm-associated antigen 11B isoform B precursor

    See identical proteins and their annotated locations for NP_478113.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) has an alternate 5' UTR compared to variant A. The N-terminus of the encoded isoform (B) is identical to that of isoform E, but the remainder of the protein is identical to isoform A.
    Source sequence(s)
    AC130360, AF168616
    UniProtKB/Swiss-Prot
    Q08648
    Related
    ENSP00000431230.1, ENST00000528168.3
  7. NM_058207.4NP_478114.2  sperm-associated antigen 11B isoform E precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) has an alternate 5' UTR and lacks one internal exon, compared to variant A. The N-terminus of the encoded isoform (E) is identical to isoform B, and its C-terminus is identical to isoform D. Isoform E has a region of similarity to beta-defensins.
    Source sequence(s)
    AA694479, AC130360
    UniProtKB/Swiss-Prot
    Q08648
    Related
    ENSP00000398550.1, ENST00000458665.5
    Conserved Domains (1) summary
    pfam00711
    Location:2760
    Defensin_beta; Beta defensin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    7447754..7463542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    5445301..5461083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187570.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    130827..146652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center