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Cdh22 cadherin 22 [ Mus musculus (house mouse) ]

Gene ID: 104010, updated on 5-Mar-2024

Summary

Official Symbol
Cdh22provided by MGI
Official Full Name
cadherin 22provided by MGI
Primary source
MGI:MGI:1341843
See related
Ensembl:ENSMUSG00000053166 AllianceGenome:MGI:1341843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including central nervous system; heart; limb; limb bud; and retina. Orthologous to human CDH22 (cadherin 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 8.6), frontal lobe adult (RPKM 5.4) and 8 other tissues See more
Orthologs
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Genomic context

See Cdh22 in Genome Data Viewer
Location:
2 H3; 2 85.43 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164953421..165076892, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165111501..165234924, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700025C18 gene Neighboring gene STARR-seq mESC enhancer starr_06347 Neighboring gene predicted gene, 36690 Neighboring gene predicted gene, 36803 Neighboring gene predicted gene, 36748 Neighboring gene predicted gene, 25569 Neighboring gene solute carrier family 35, member C2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cadherin-22
Names
PB-cadherin
pituitary and brain cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174988.3NP_778153.2  cadherin-22 precursor

    See identical proteins and their annotated locations for NP_778153.2

    Status: VALIDATED

    Source sequence(s)
    AK140248, AL591411, BC112407
    Consensus CDS
    CCDS17073.1
    UniProtKB/Swiss-Prot
    I7HIP9, Q9WTP5
    Related
    ENSMUSP00000066864.7, ENSMUST00000065438.13
    Conserved Domains (2) summary
    cd11304
    Location:398492
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:645804
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164953421..165076892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157158.1XP_036013051.1  cadherin-22 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:276370
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:523682
    Cadherin_C; Cadherin cytoplasmic region
  2. XM_006498536.5XP_006498599.1  cadherin-22 isoform X4

    Conserved Domains (3) summary
    cd11304
    Location:95193
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:2290
    CA; Cadherin repeats
    pfam01049
    Location:241400
    Cadherin_C; Cadherin cytoplasmic region
  3. XM_036157156.1XP_036013049.1  cadherin-22 isoform X1

    UniProtKB/Swiss-Prot
    I7HIP9, Q9WTP5
    Conserved Domains (2) summary
    cd11304
    Location:398492
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:645804
    Cadherin_C; Cadherin cytoplasmic region
  4. XM_006498534.4XP_006498597.1  cadherin-22 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:276370
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:523682
    Cadherin_C; Cadherin cytoplasmic region
  5. XM_030246473.2XP_030102333.1  cadherin-22 isoform X3

    Conserved Domains (1) summary
    cd11304
    Location:398492
    Cadherin_repeat; Cadherin tandem repeat domain

RNA

  1. XR_003949827.2 RNA Sequence

  2. XR_004937403.1 RNA Sequence