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MYL9 myosin light chain 9 [ Homo sapiens (human) ]

Gene ID: 10398, updated on 21-Dec-2019

Summary

Official Symbol
MYL9provided by HGNC
Official Full Name
myosin light chain 9provided by HGNC
Primary source
HGNC:HGNC:15754
See related
Ensembl:ENSG00000101335 MIM:609905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC20; MLC2; MRLC1; MYRL2; MLC-2C
Summary
Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 922.2), urinary bladder (RPKM 715.8) and 17 other tissues See more
Orthologs

Genomic context

See MYL9 in Genome Data Viewer
Location:
20q11.23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (36541519..36551447)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35169887..35178226)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372602 Neighboring gene AAR2 splicing factor Neighboring gene DLG associated protein 4 Neighboring gene DLGAP4 antisense RNA 1 Neighboring gene TGIF2-RAB5IF readthrough Neighboring gene uncharacterized LOC107985397 Neighboring gene TGFB induced factor homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3505

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
myosin heavy chain binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
muscle contraction TAS
Traceable Author Statement
more info
 
platelet aggregation HMP PubMed 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
regulation of muscle contraction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Z disc IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
muscle myosin complex TAS
Traceable Author Statement
more info
PubMed 
stress fiber IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin regulatory light polypeptide 9
Names
20 kDa myosin light chain
epididymis secretory sperm binding protein
myosin RLC
myosin regulatory light chain 1
myosin regulatory light chain 2, smooth muscle isoform
myosin regulatory light chain 9
myosin regulatory light chain MRLC1
myosin, light chain 9, regulatory
myosin, light polypeptide 9, regulatory

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006097.5NP_006088.2  myosin regulatory light polypeptide 9 isoform a

    See identical proteins and their annotated locations for NP_006088.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK130879, AL050318, BC002648
    Consensus CDS
    CCDS13276.1
    UniProtKB/Swiss-Prot
    P24844
    Related
    ENSP00000279022.2, ENST00000279022.7
    Conserved Domains (1) summary
    COG5126
    Location:19169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_181526.3NP_852667.1  myosin regulatory light polypeptide 9 isoform b

    See identical proteins and their annotated locations for NP_852667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AL050318, AL697699, BC002648
    Consensus CDS
    CCDS13277.1
    UniProtKB/Swiss-Prot
    P24844
    Related
    ENSP00000217313.2, ENST00000346786.2
    Conserved Domains (1) summary
    cl25352
    Location:19115
    EFh_PEF; The penta-EF hand (PEF) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    36541519..36551447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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