U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MYL9 myosin light chain 9 [ Homo sapiens (human) ]

Gene ID: 10398, updated on 21-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
MYL9provided by HGNC
Official Full Name
myosin light chain 9provided by HGNC
Primary source
HGNC:HGNC:15754
See related
Ensembl:ENSG00000101335 MIM:609905; AllianceGenome:HGNC:15754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC20; MLC2; MRLC1; MYRL2; MLC-2C; MMIHS4
Summary
Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 922.2), urinary bladder (RPKM 715.8) and 17 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MYL9 in Genome Data Viewer
Location:
20q11.23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (36541519..36551447)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (38265393..38275321)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35169922..35179850)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene DLG associated protein 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35100944-35101844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35125835-35126334 Neighboring gene DLGAP4 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35170723-35171376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35171377-35172030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35172031-35172684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35172685-35173338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35175959-35176887 Neighboring gene NANOG hESC enhancer GRCh37_chr20:35191013-35191578 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr20:35199946-35200498

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Increased Myosin light chain 9 expression during Kawasaki disease vasculitis. Kobayashi H, et al. Front Immunol, 2022. PMID 36685558, Free PMC Article
  2. Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity. Iwamura C, et al. Proc Natl Acad Sci U S A, 2022 Aug 16. PMID 35895716, Free PMC Article
  3. Research progress in myosin light chain 9 in malignant tumors. You Y, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Oct 28. PMID 34911847
  4. Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma. Matsushita K, et al. Cancer Rep (Hoboken), 2022 Oct. PMID 34821071, Free PMC Article
  5. The landscape of prognostic and immunological role of myosin light chain 9 (MYL9) in human tumors. Lv M, et al. Immun Inflamm Dis, 2022 Feb. PMID 34729929, Free PMC Article

See all (65) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased Myosin light chain 9 expression during Kawasaki disease vasculitis.
    Title: Increased Myosin light chain 9 expression during Kawasaki disease vasculitis.
  2. Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma.
    Title: Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma.
  3. Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity.
    Title: Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity.
  4. The landscape of prognostic and immunological role of myosin light chain 9 (MYL9) in human tumors.
    Title: The landscape of prognostic and immunological role of myosin light chain 9 (MYL9) in human tumors.
  5. CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system.
    Title: CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69-Myl9 system.
  6. Myosin light chain 9 promotes the proliferation, invasion, migration and angiogenesis of colorectal cancer cells by binding to Yes-associated protein 1 and regulating Hippo signaling.
    Title: Myosin light chain 9 promotes the proliferation, invasion, migration and angiogenesis of colorectal cancer cells by binding to Yes-associated protein 1 and regulating Hippo signaling.
  7. High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer.
    Title: High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer.
  8. Research progress in myosin light chain 9 in malignant tumors.", trans "9.
    Title: Research progress in myosin light chain 9 in malignant tumors.
  9. Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease.
    Title: Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease.
  10. The association of high MYL9 expression with poor prognosis in newly diagnosed glioblastoma (GBM) patients and increased expression in recurrent GBM is indicative of its role in conferring tumour aggressiveness.
    Title: Expression pattern and prognostic significance of myosin light chain 9 (MYL9): a novel biomarker in glioblastoma.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Megacystis-microcolon-intestinal hypoperistalsis syndrome 4
MedGen: C5543519 OMIM: 619365 GeneReviews: Not available
Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC3505

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables myosin heavy chain binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in platelet aggregation HMP PubMed 
involved_in regulation of muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of muscle myosin complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
myosin regulatory light polypeptide 9
Names
20 kDa myosin light chain
epididymis secretory sperm binding protein
myosin RLC
myosin regulatory light chain 1
myosin regulatory light chain 9
myosin regulatory light chain MRLC1
myosin, light chain 9, regulatory
myosin, light polypeptide 9, regulatory

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006097.5 → NP_006088.2  myosin regulatory light polypeptide 9 isoform a

    See identical proteins and their annotated locations for NP_006088.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK130879, AL050318, BC002648
    Consensus CDS
    CCDS13276.1
    UniProtKB/Swiss-Prot
    P24844, Q9H136
    UniProtKB/TrEMBL
    A0A384NY64
    Related
    ENSP00000279022.2, ENST00000279022.7
    Conserved Domains (1) summary
    COG5126
    Location:19 → 169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_181526.3 → NP_852667.1  myosin regulatory light polypeptide 9 isoform b

    See identical proteins and their annotated locations for NP_852667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AL050318, AL697699, BC002648
    Consensus CDS
    CCDS13277.1
    UniProtKB/Swiss-Prot
    P24844
    Related
    ENSP00000217313.2, ENST00000346786.2
    Conserved Domains (1) summary
    COG5126
    Location:19 → 115
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    36541519..36551447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    38265393..38275321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24844.4 GenPept UniProtKB/Swiss-Prot:P24844

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous