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Dnm3 dynamin 3 [ Mus musculus (house mouse) ]

Gene ID: 103967, updated on 16-Apr-2024

Summary

Official Symbol
Dnm3provided by MGI
Official Full Name
dynamin 3provided by MGI
Primary source
MGI:MGI:1341299
See related
Ensembl:ENSMUSG00000040265 AllianceGenome:MGI:1341299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dyna III; mKIAA0820; C530045C17; 9630020E24Rik; B230343F03Rik
Summary
Predicted to enable several functions, including G protein-coupled glutamate receptor binding activity; GTPase activity; and nitric-oxide synthase binding activity. Predicted to be a structural constituent of postsynapse. Involved in synaptic vesicle budding from presynaptic endocytic zone membrane. Located in photoreceptor inner segment and presynapse. Is expressed in several structures, including 1st branchial arch; central nervous system; genitourinary system; musculature; and paraxial mesenchyme. Orthologous to human DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 19.2), CNS E18 (RPKM 12.1) and 7 other tissues See more
Orthologs
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Genomic context

Location:
1 H2.1; 1 69.95 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161810022..162305890, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161982450..162478321, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02830 Neighboring gene RIKEN cDNA 4930558K02 gene Neighboring gene predicted gene, 31925 Neighboring gene STARR-positive B cell enhancer ABC_E4367 Neighboring gene STARR-positive B cell enhancer mm9_chr1:163906574-163906875 Neighboring gene STARR-seq mESC enhancer starr_02833 Neighboring gene RIKEN cDNA 2810442N19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163930050-163930233 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C Neighboring gene STARR-seq mESC enhancer starr_02834 Neighboring gene VISTA enhancer mm712 Neighboring gene STARR-seq mESC enhancer starr_02835 Neighboring gene STARR-seq mESC enhancer starr_02836 Neighboring gene STARR-seq mESC enhancer starr_02837 Neighboring gene microRNA 199a-2 Neighboring gene dynamin 3, opposite strand Neighboring gene microRNA 214 Neighboring gene STARR-seq mESC enhancer starr_02838 Neighboring gene STARR-seq mESC enhancer starr_02839 Neighboring gene STARR-seq mESC enhancer starr_02840 Neighboring gene predicted gene, 39688 Neighboring gene predicted gene, 31985 Neighboring gene predicted gene, 46247 Neighboring gene methyltransferase 13, eEF1A lysine and N-terminal methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of postsynapse ISO
Inferred from Sequence Orthology
more info
 
enables type 1 metabotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 5 metabotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of apical tubulobulbar complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
part_of basal tubulobulbar complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine head ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic cleft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynamin-3
Names
dynamin III
t-dynamin
testicular dynamin
NP_001033708.1
NP_766234.1
XP_006496664.1
XP_006496665.1
XP_006496666.1
XP_006496667.1
XP_006496668.1
XP_030110486.1
XP_036021487.1
XP_036021507.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038619.2NP_001033708.1  dynamin-3 isoform 1

    See identical proteins and their annotated locations for NP_001033708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK046124, AK049724, AK147678, AW047427
    UniProtKB/Swiss-Prot
    B2RUH0, Q3UGY9, Q80TR2, Q8BWW6, Q8BZ98
    UniProtKB/TrEMBL
    E9QLL2
    Conserved Domains (6) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79738
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651739
    GED; Dynamin GTPase effector domain
    pfam15087
    Location:748831
    DUF4551; Protein of unknown function (DUF4551)
  2. NM_172646.3NP_766234.1  dynamin-3 isoform 2

    See identical proteins and their annotated locations for NP_766234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 2).
    Source sequence(s)
    AK046124, AK049724, AK147678, AW047427
    Consensus CDS
    CCDS48417.1
    UniProtKB/TrEMBL
    E9QLL2
    Related
    ENSMUSP00000064538.8, ENSMUST00000070330.14
    Conserved Domains (6) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79734
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647735
    GED; Dynamin GTPase effector domain
    pfam15087
    Location:744827
    DUF4551; Protein of unknown function (DUF4551)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    161810022..162305890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165594.1XP_036021487.1  dynamin-3 isoform X6

    UniProtKB/TrEMBL
    E9QLL2
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657745
    GED; Dynamin GTPase effector domain
    pfam06346
    Location:753838
    Drf_FH1; Formin Homology Region 1
  2. XM_006496604.5XP_006496667.1  dynamin-3 isoform X4

    UniProtKB/TrEMBL
    E9QLL2
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03307
    Location:752842
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:660749
    GED; Dynamin GTPase effector domain
  3. XM_036165614.1XP_036021507.1  dynamin-3 isoform X7

    UniProtKB/TrEMBL
    E9QLL2
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:738841
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647735
    GED; Dynamin GTPase effector domain
  4. XM_006496602.4XP_006496665.1  dynamin-3 isoform X2

    UniProtKB/TrEMBL
    E9QLL2
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam15822
    Location:753841
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
  5. XM_030254626.2XP_030110486.1  dynamin-3 isoform X5

    UniProtKB/TrEMBL
    E9QLL2
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam15822
    Location:753843
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
  6. XM_006496601.4XP_006496664.1  dynamin-3 isoform X1

    UniProtKB/TrEMBL
    E9QLL2
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam15822
    Location:757845
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:660749
    GED; Dynamin GTPase effector domain
  7. XM_006496603.5XP_006496666.1  dynamin-3 isoform X3

    UniProtKB/TrEMBL
    E9QLL2
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    cd01256
    Location:526635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam15822
    Location:757847
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:660749
    GED; Dynamin GTPase effector domain
  8. XM_006496605.4XP_006496668.1  dynamin-3 isoform X8

    Conserved Domains (2) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region

RNA

  1. XR_004942603.1 RNA Sequence

  2. XR_004942591.1 RNA Sequence