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ANAPC10 anaphase promoting complex subunit 10 [ Homo sapiens (human) ]

Gene ID: 10393, updated on 8-Jul-2021

Summary

Official Symbol
ANAPC10provided by HGNC
Official Full Name
anaphase promoting complex subunit 10provided by HGNC
Primary source
HGNC:HGNC:24077
See related
Ensembl:ENSG00000164162 MIM:613745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOC1; APC10
Summary
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Expression
Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

See ANAPC10 in Genome Data Viewer
Location:
4q31.21
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (144967117..145098571, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (145915727..146019723, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene hedgehog interacting protein Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 5 Neighboring gene RN7SK pseudogene 235 Neighboring gene ATP binding cassette subfamily E member 1 Neighboring gene OTU deubiquitinase 4 Neighboring gene uncharacterized LOC105377465

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564L0562

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit 10
Names
cyclosome subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256706.2NP_001243635.1  anaphase-promoting complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_001243635.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC097649, AF132794, AL080090, BF693880, BU175327
    Consensus CDS
    CCDS43273.1
    UniProtKB/Swiss-Prot
    Q9UM13
    Related
    ENSP00000423995.1, ENST00000507656.6
    Conserved Domains (1) summary
    pfam03256
    Location:4183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  2. NM_001256707.2NP_001243636.1  anaphase-promoting complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_001243636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC097649, AL080090, BF693880, CV023091
    Consensus CDS
    CCDS43273.1
    UniProtKB/Swiss-Prot
    Q9UM13
    Related
    ENSP00000403891.2, ENST00000451299.6
    Conserved Domains (1) summary
    pfam03256
    Location:4183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  3. NM_001256708.2NP_001243637.1  anaphase-promoting complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_001243637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC096757, AC097649, BU567906, CV023091
    Consensus CDS
    CCDS43273.1
    UniProtKB/Swiss-Prot
    Q9UM13
    Related
    ENSP00000478501.1, ENST00000613466.4
    Conserved Domains (1) summary
    pfam03256
    Location:4183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  4. NM_001256709.2NP_001243638.1  anaphase-promoting complex subunit 10 isoform 2

    See identical proteins and their annotated locations for NP_001243638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC097649, AL080090, BF693880, BG494966
    UniProtKB/Swiss-Prot
    Q9UM13
    Conserved Domains (1) summary
    pfam03256
    Location:15194
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  5. NM_001256710.2NP_001243639.1  anaphase-promoting complex subunit 10 isoform 3

    See identical proteins and their annotated locations for NP_001243639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097649, AL080090, BF693880, CN305215
    UniProtKB/Swiss-Prot
    Q9UM13
    Conserved Domains (1) summary
    cl02148
    Location:4109
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  6. NM_001256711.2NP_001243640.1  anaphase-promoting complex subunit 10 isoform 3

    See identical proteins and their annotated locations for NP_001243640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097649, BF693880, BG530912, CN305215
    Conserved Domains (1) summary
    cl02148
    Location:4109
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  7. NM_001256712.2NP_001243641.1  anaphase-promoting complex subunit 10 isoform 4

    See identical proteins and their annotated locations for NP_001243641.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097649, AV757106, BF693880
    Related
    ENSP00000424463.1, ENST00000502847.1
    Conserved Domains (1) summary
    cl02148
    Location:469
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  8. NM_001318367.2NP_001305296.1  anaphase-promoting complex subunit 10 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains an alternate 5' terminal exon compared to variant 1. This difference results in a distinct 5' UTR, translation initiation at an alternate start codon, and a novel 5' coding region compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB012109, AC096757, AC097649, AW025455, BI913723
    UniProtKB/Swiss-Prot
    Q9UM13
    Conserved Domains (1) summary
    pfam03256
    Location:38217
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  9. NM_014885.5NP_055700.2  anaphase-promoting complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_055700.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AB012109, AC097649
    Consensus CDS
    CCDS43273.1
    UniProtKB/Swiss-Prot
    Q9UM13
    Related
    ENSP00000310071.5, ENST00000309439.9
    Conserved Domains (1) summary
    pfam03256
    Location:4183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

RNA

  1. NR_046345.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC097649, BF693880, BI488888

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    144967117..145098571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531532.2XP_011529834.1  anaphase-promoting complex subunit 10 isoform X13

    See identical proteins and their annotated locations for XP_011529834.1

    Related
    ENST00000506851.5
    Conserved Domains (1) summary
    cl02148
    Location:4110
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  2. XM_011531529.2XP_011529831.1  anaphase-promoting complex subunit 10 isoform X10

    Conserved Domains (1) summary
    cl02148
    Location:42148
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  3. XM_011531531.3XP_011529833.1  anaphase-promoting complex subunit 10 isoform X11

    Conserved Domains (1) summary
    cl02148
    Location:42107
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  4. XM_017007644.2XP_016863133.1  anaphase-promoting complex subunit 10 isoform X12

    Conserved Domains (1) summary
    cl02148
    Location:4109
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  5. XM_024453875.1XP_024309643.1  anaphase-promoting complex subunit 10 isoform X4

    Conserved Domains (1) summary
    pfam03256
    Location:4183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  6. XM_011531524.3XP_011529826.1  anaphase-promoting complex subunit 10 isoform X4

    See identical proteins and their annotated locations for XP_011529826.1

    UniProtKB/Swiss-Prot
    Q9UM13
    Conserved Domains (1) summary
    pfam03256
    Location:4183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  7. XM_017007639.2XP_016863128.1  anaphase-promoting complex subunit 10 isoform X2

    Conserved Domains (1) summary
    pfam03256
    Location:38217
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  8. XM_017007640.2XP_016863129.1  anaphase-promoting complex subunit 10 isoform X3

    Conserved Domains (1) summary
    pfam03256
    Location:15194
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
  9. XM_011531525.2XP_011529827.1  anaphase-promoting complex subunit 10 isoform X5

    Related
    ENST00000502562.5
    Conserved Domains (1) summary
    cl02148
    Location:42149
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  10. XM_017007641.1XP_016863130.1  anaphase-promoting complex subunit 10 isoform X6

  11. XM_017007642.1XP_016863131.1  anaphase-promoting complex subunit 10 isoform X8

  12. XM_011531527.2XP_011529829.1  anaphase-promoting complex subunit 10 isoform X7

    Conserved Domains (1) summary
    cl02148
    Location:42148
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
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