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NOD1 nucleotide binding oligomerization domain containing 1 [ Homo sapiens (human) ]

Gene ID: 10392, updated on 23-Dec-2018

Summary

Official Symbol
NOD1provided by HGNC
Official Full Name
nucleotide binding oligomerization domain containing 1provided by HGNC
Primary source
HGNC:HGNC:16390
See related
Ensembl:ENSG00000106100 MIM:605980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CARD4; NLRC1; CLR7.1
Summary
This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in lung (RPKM 5.7), spleen (RPKM 4.5) and 24 other tissues See more
Orthologs

Genomic context

See NOD1 in Genome Data Viewer
Location:
7p14.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (30424527..30478866, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30464143..30518426, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized protein DKFZp586I1420 Neighboring gene long intergenic non-protein coding RNA 1176 Neighboring gene uncharacterized LOC101928268 Neighboring gene gamma-glutamylcyclotransferase Neighboring gene golgin A8 family member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
    Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
  • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
    Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystem (from REACTOME)
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystemC-Jun NH2 terminal kinases (JNKs) are an evolutionarily conserved family of serine/threonine protein kinases, that belong to mitogen activated protein kinase family (MAPKs - also known as stress-acti...
  • MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
    MAP kinase activation in TLR cascade, organism-specific biosystemThe mitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascad...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
    MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
  • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
    MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
    NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
  • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
    Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...
  • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
  • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
    Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
  • Pertussis, organism-specific biosystem (from KEGG)
    Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Pertussis, conserved biosystem (from KEGG)
    Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Shigellosis, organism-specific biosystem (from KEGG)
    Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • activated TAK1 mediates p38 MAPK activation, organism-specific biosystem (from REACTOME)
    activated TAK1 mediates p38 MAPK activation, organism-specific biosystemp38 mitogen-activated protein kinase (MAPK) belongs to a highly conserved family of serine/threonine protein kinases. The p38 MAPK-dependent signaling cascade is activated by pro-inflammatory or stre...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CARD domain binding IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
peptidoglycan binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
JNK cascade TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to muramyl dipeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response TAS
Traceable Author Statement
more info
PubMed 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of biotic stimulus TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-8 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendritic cell antigen processing and presentation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of xenophagy IEA
Inferred from Electronic Annotation
more info
 
protein complex oligomerization TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nucleotide-binding oligomerization domain-containing protein 1
Names
NLR family, CARD domain containing 1
caspase recruitment domain family, member 4
caspase recruitment domain-containing protein 4
nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013025.1 RefSeqGene

    Range
    4912..59251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001354849.1NP_001341778.1  nucleotide-binding oligomerization domain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AA845215, AC005154, AC006027
    Conserved Domains (5) summary
    COG5635
    Location:170542
    COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
    cl26161
    Location:676914
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_006092.4NP_006083.1  nucleotide-binding oligomerization domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006083.1

    Status: REVIEWED

    Source sequence(s)
    AA845215, AC005154, AF113925, BC040339, CV569884
    Consensus CDS
    CCDS5427.1
    UniProtKB/Swiss-Prot
    Q9Y239
    UniProtKB/TrEMBL
    A0A024RA73
    Related
    ENSP00000222823.4, ENST00000222823.8
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:676941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain

RNA

  1. NR_149002.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA845215, AC005154, AF113925, AK023969

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    30424527..30478866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515081.2XP_011513383.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011513383.1

    UniProtKB/Swiss-Prot
    Q9Y239
    UniProtKB/TrEMBL
    A0A024RA73
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:676941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  2. XM_005249572.1XP_005249629.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005249629.1

    UniProtKB/Swiss-Prot
    Q9Y239
    UniProtKB/TrEMBL
    A0A024RA73
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:676941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  3. XM_011515079.1XP_011513381.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011513381.1

    UniProtKB/Swiss-Prot
    Q9Y239
    UniProtKB/TrEMBL
    A0A024RA73
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:676941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  4. XM_011515083.1XP_011513385.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:676925
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  5. XM_011515085.1XP_011513387.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X5

    Conserved Domains (4) summary
    cd00116
    Location:723858
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730754
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  6. XM_011515084.1XP_011513386.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X4

    Conserved Domains (5) summary
    COG5635
    Location:170542
    COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
    cl26161
    Location:676914
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  7. XM_005249568.1XP_005249625.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005249625.1

    UniProtKB/Swiss-Prot
    Q9Y239
    UniProtKB/TrEMBL
    A0A024RA73
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:676941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  8. XM_006715633.2XP_006715696.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715696.1

    UniProtKB/Swiss-Prot
    Q9Y239
    UniProtKB/TrEMBL
    A0A024RA73
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:676941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  9. XM_011515080.2XP_011513382.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011513382.1

    UniProtKB/Swiss-Prot
    Q9Y239
    UniProtKB/TrEMBL
    A0A024RA73
    Conserved Domains (5) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd00116
    Location:676941
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  10. XM_005249576.1XP_005249633.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X8

    Conserved Domains (3) summary
    cd00116
    Location:428693
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:482509
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:3119
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  11. XM_017011674.1XP_016867163.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X3

  12. XM_011515087.1XP_011513389.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X6

    Conserved Domains (5) summary
    COG5635
    Location:89542
    COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]
    cd00116
    Location:723821
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    sd00033
    Location:730757
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:197367
    NACHT; NACHT domain
  13. XM_011515088.2XP_011513390.1  nucleotide-binding oligomerization domain-containing protein 1 isoform X7

    See identical proteins and their annotated locations for XP_011513390.1

    UniProtKB/TrEMBL
    G3XAL1
    Related
    ENSP00000416946.1, ENST00000434755.5
    Conserved Domains (3) summary
    smart00382
    Location:194291
    AAA; ATPases associated with a variety of cellular activities
    cd08324
    Location:21105
    CARD_NOD1_CARD4; Caspase activation and recruitment domain similar to that found in NOD1
    pfam05729
    Location:197367
    NACHT; NACHT domain

RNA

  1. XR_002956406.1 RNA Sequence

  2. XR_926908.2 RNA Sequence

  3. XR_001744529.1 RNA Sequence

  4. XR_926909.2 RNA Sequence

  5. XR_926910.1 RNA Sequence

  6. XR_001744530.1 RNA Sequence

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