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CORO2B coronin 2B [ Homo sapiens (human) ]

Gene ID: 10391, updated on 24-Nov-2020

Summary

Official Symbol
CORO2Bprovided by HGNC
Official Full Name
coronin 2Bprovided by HGNC
Primary source
HGNC:HGNC:2256
See related
Ensembl:ENSG00000103647 MIM:605002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLIPINC
Expression
Biased expression in brain (RPKM 22.9), ovary (RPKM 6.5) and 11 other tissues See more
Orthologs

Genomic context

See CORO2B in Genome Data Viewer
Location:
15q23
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (68518373..68727806)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68851614..69020145)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha 11 Neighboring gene uncharacterized LOC105370873 Neighboring gene Sharpr-MPRA regulatory region 237 Neighboring gene heart enhancer 11 Neighboring gene cysteinyl-tRNA synthetase 1 pseudogene 1 Neighboring gene acidic nuclear phosphoprotein 32 family member A Neighboring gene microRNA 4312

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0925

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding NAS
Non-traceable Author Statement
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
talin binding IDA
Inferred from Direct Assay
more info
PubMed 
vinculin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
coronin-2B
Names
clipin C
coronin, actin binding protein, 2B
coronin-like protein C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190456.2NP_001177385.1  coronin-2B isoform 2

    See identical proteins and their annotated locations for NP_001177385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC090734, AC105014, AI871484, AK289678, DA128408
    Consensus CDS
    CCDS53952.1
    UniProtKB/Swiss-Prot
    Q9UQ03
    Related
    ENSP00000446250.1, ENST00000540068.6
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001190457.2NP_001177386.1  coronin-2B isoform 2

    See identical proteins and their annotated locations for NP_001177386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC090734, AI871484, AK289678
    Consensus CDS
    CCDS53952.1
    UniProtKB/Swiss-Prot
    Q9UQ03
    Related
    ENSP00000443819.1, ENST00000543950.3
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001324014.1NP_001310943.1  coronin-2B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090259, AC090734, AC100825, AC105014
    Consensus CDS
    CCDS53952.1
    UniProtKB/Swiss-Prot
    Q9UQ03
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001324015.1NP_001310944.1  coronin-2B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090734, AC105014
    Consensus CDS
    CCDS53952.1
    UniProtKB/Swiss-Prot
    Q9UQ03
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_006091.5NP_006082.3  coronin-2B isoform 1

    See identical proteins and their annotated locations for NP_006082.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB023142, AC090734, AC105014, BQ184259, HY150896
    Consensus CDS
    CCDS10229.2
    UniProtKB/Swiss-Prot
    Q9UQ03
    Related
    ENSP00000261861.6, ENST00000261861.10
    Conserved Domains (2) summary
    sd00039
    Location:4585
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:15460
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    68518373..68727806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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