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SYCP2 synaptonemal complex protein 2 [ Homo sapiens (human) ]

Gene ID: 10388, updated on 18-Aug-2020

Summary

Official Symbol
SYCP2provided by HGNC
Official Full Name
synaptonemal complex protein 2provided by HGNC
Primary source
HGNC:HGNC:11490
See related
Ensembl:ENSG00000196074 MIM:604105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCP2; SCP-2; SPGF1
Summary
The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 17.7), stomach (RPKM 1.7) and 4 other tissues See more
Orthologs

Genomic context

See SYCP2 in Genome Data Viewer
Location:
20q13.33
Exon count:
47
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (59863277..59933700, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (58438612..58508704, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene phosphatase and actin regulator 3 Neighboring gene PHACTR3 antisense RNA 1 Neighboring gene RNA, U7 small nuclear 141 pseudogene Neighboring gene family with sequence similarity 217 member B Neighboring gene protein phosphatase 1 regulatory subunit 3D Neighboring gene cadherin 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
female meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fertilization IEA
Inferred from Electronic Annotation
more info
 
male genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
male meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic G1 phase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
synaptonemal complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
condensed nuclear chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral element IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral element ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
synaptonemal complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
synaptonemal complex protein 2
Names
synaptonemal complex lateral element protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046980.1 RefSeqGene

    Range
    5045..75111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014258.4NP_055073.2  synaptonemal complex protein 2

    See identical proteins and their annotated locations for NP_055073.2

    Status: REVIEWED

    Source sequence(s)
    AL109928, AL158092, BX649108, DB636651
    Consensus CDS
    CCDS13482.1
    UniProtKB/Swiss-Prot
    Q9BX26
    Related
    ENSP00000350162.2, ENST00000357552.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    59863277..59933700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528493.2XP_011526795.1  synaptonemal complex protein 2 isoform X7

  2. XM_011528490.3XP_011526792.1  synaptonemal complex protein 2 isoform X4

  3. XM_011528487.3XP_011526789.1  synaptonemal complex protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011526789.1

  4. XM_017027590.2XP_016883079.1  synaptonemal complex protein 2 isoform X7

  5. XM_011528489.2XP_011526791.1  synaptonemal complex protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011526791.1

    UniProtKB/Swiss-Prot
    Q9BX26
  6. XM_011528488.2XP_011526790.1  synaptonemal complex protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011526790.1

  7. XM_017027589.1XP_016883078.1  synaptonemal complex protein 2 isoform X6

  8. XM_017027588.1XP_016883077.1  synaptonemal complex protein 2 isoform X5

  9. XM_017027587.1XP_016883076.1  synaptonemal complex protein 2 isoform X2

  10. XM_017027586.1XP_016883075.1  synaptonemal complex protein 2 isoform X1

  11. XM_017027591.1XP_016883080.1  synaptonemal complex protein 2 isoform X8

  12. XM_017027592.2XP_016883081.1  synaptonemal complex protein 2 isoform X9

    Related
    ENSP00000402456.1, ENST00000446834.5
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