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Inca1 inhibitor of CDK, cyclin A1 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 103844, updated on 26-Sep-2022

Summary

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Official Symbol
Inca1provided by MGI
Official Full Name
inhibitor of CDK, cyclin A1 interacting protein 1provided by MGI
Primary source
MGI:MGI:2144284
See related
Ensembl:ENSMUSG00000057054 AllianceGenome:MGI:2144284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cyclin binding activity. Acts upstream of or within negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and positive regulation of apoptotic signaling pathway. Predicted to be located in nuclear body. Predicted to be active in cytoplasm. Is expressed in female reproductive system; germ cell of ovary; and ovary. Orthologous to human INCA1 (inhibitor of CDK, cyclin A1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 8.3), testis adult (RPKM 7.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Inca1 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70579187..70593177, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70688361..70700285, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 7 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene kinesin family member 1C Neighboring gene microRNA 6925 Neighboring gene predicted gene 12320

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1. Bäumer N, et al. PLoS One, 2014. PMID 25525809, Free PMC Article
  2. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. Bäumer N, et al. J Biol Chem, 2011 Aug 12. PMID 21540187, Free PMC Article
  3. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. Zhang F, et al. PLoS One, 2011. PMID 21750715, Free PMC Article
  4. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. Diederichs S, et al. J Biol Chem, 2004 Aug 6. PMID 15159402
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (18) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables cyclin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of fibroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fibroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein INCA1
Names
inhibitor of CDK interacting with cyclin A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252482.1 → NP_001239411.1  protein INCA1 isoform 1

    See identical proteins and their annotated locations for NP_001239411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform 1).
    Source sequence(s)
    AY601910
    Consensus CDS
    CCDS24964.1
    UniProtKB/Swiss-Prot
    Q4VAE2, Q6PKN7
    Related
    ENSMUSP00000118761.3, ENSMUST00000126114.9
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 187
    INCA1

  2. NM_001252483.1 → NP_001239412.1  protein INCA1 isoform 1

    See identical proteins and their annotated locations for NP_001239412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform 1).
    Source sequence(s)
    AY601911
    Consensus CDS
    CCDS24964.1
    UniProtKB/Swiss-Prot
    Q4VAE2, Q6PKN7
    Related
    ENSMUSP00000104181.3, ENSMUST00000108541.9
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 187
    INCA1

  3. NM_001252484.1 → NP_001239413.1  protein INCA1 isoform 1

    See identical proteins and their annotated locations for NP_001239413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform 1).
    Source sequence(s)
    AY601912
    Consensus CDS
    CCDS24964.1
    UniProtKB/Swiss-Prot
    Q4VAE2, Q6PKN7
    Related
    ENSMUSP00000104182.2, ENSMUST00000108542.8
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 187
    INCA1

  4. NM_001252485.1 → NP_001239414.1  protein INCA1 isoform 2

    See identical proteins and their annotated locations for NP_001239414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' sequence, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL596117
    Consensus CDS
    CCDS56789.1
    UniProtKB/Swiss-Prot
    Q6PKN7
    Related
    ENSMUSP00000104183.4, ENSMUST00000108543.4
    Conserved Domains (1) summary
    pfam15142
    Location:1 → 152
    INCA1

  5. NM_213729.1 → NP_998894.1  protein INCA1 isoform 1

    See identical proteins and their annotated locations for NP_998894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variants 2-4 encode the same protein (isoform 1).
    Source sequence(s)
    AY601909
    Consensus CDS
    CCDS24964.1
    UniProtKB/Swiss-Prot
    Q4VAE2, Q6PKN7
    Related
    ENSMUSP00000073311.2, ENSMUST00000073625.8
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 187
    INCA1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70579187..70593177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156197.1 → XP_036012090.1  protein INCA1 isoform X2

    Conserved Domains (1) summary
    pfam15142
    Location:1 → 152
    INCA1

  2. XM_006531928.5 → XP_006531991.1  protein INCA1 isoform X2

    See identical proteins and their annotated locations for XP_006531991.1

    UniProtKB/Swiss-Prot
    Q6PKN7
    Conserved Domains (1) summary
    pfam15142
    Location:1 → 152
    INCA1

  3. XM_036156196.1 → XP_036012089.1  protein INCA1 isoform X2

    Conserved Domains (1) summary
    pfam15142
    Location:1 → 152
    INCA1

  4. XM_036156195.1 → XP_036012088.1  protein INCA1 isoform X2

    Conserved Domains (1) summary
    pfam15142
    Location:1 → 152
    INCA1

  5. XM_036156194.1 → XP_036012087.1  protein INCA1 isoform X1

    UniProtKB/Swiss-Prot
    Q4VAE2
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 187
    INCA1

  6. XM_036156198.1 → XP_036012091.1  protein INCA1 isoform X3

    Conserved Domains (1) summary
    pfam15142
    Location:12 → 109
    INCA1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PKN7.1 GenPept UniProtKB/Swiss-Prot:Q6PKN7

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