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BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 [ Homo sapiens (human) ]

Gene ID: 10380, updated on 24-Nov-2020

Summary

Official Symbol
BPNT1provided by HGNC
Official Full Name
3'(2'), 5'-bisphosphate nucleotidase 1provided by HGNC
Primary source
HGNC:HGNC:1096
See related
Ensembl:ENSG00000162813 MIM:604053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIP; HEL20
Summary
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in small intestine (RPKM 11.4), duodenum (RPKM 10.5) and 24 other tissues See more
Orthologs

Genomic context

See BPNT1 in Genome Data Viewer
Location:
1q41
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (220057482..220089916, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220230824..220263249, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 10 Neighboring gene uncharacterized LOC107985281 Neighboring gene glutamyl-prolyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC105373475 Neighboring gene isoleucyl-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 215

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'(2'),5'-bisphosphate nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'(2'),5'-bisphosphate nucleotidase activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
inositol phosphate dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
3'(2'),5'-bisphosphate nucleotidase 1
Names
BPntase
PAP-inositol-1,4-phosphatase
bisphosphate 3'-nucleotidase 1
epididymis luminal protein 20
testicular tissue protein Li 29
NP_001273078.1
NP_001273079.1
NP_001273080.1
NP_006076.4
XP_005273055.1
XP_005273056.1
XP_005273057.1
XP_005273061.1
XP_005273062.1
XP_006711177.1
XP_011507365.1
XP_011507366.1
XP_011507367.1
XP_016855532.1
XP_016855533.1
XP_016855534.1
XP_016855535.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286149.2NP_001273078.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform 2

    See identical proteins and their annotated locations for NP_001273078.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC103590, AK298476
    Consensus CDS
    CCDS65787.1
    UniProtKB/Swiss-Prot
    O95861
    Conserved Domains (1) summary
    cd01640
    Location:1242
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  2. NM_001286150.2NP_001273079.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform 3

    See identical proteins and their annotated locations for NP_001273079.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC103590, AK300777
    Consensus CDS
    CCDS65788.1
    UniProtKB/Swiss-Prot
    O95861
    Related
    ENSP00000410348.2, ENST00000414869.6
    Conserved Domains (1) summary
    cd01640
    Location:11261
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  3. NM_001286151.2NP_001273080.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform 2

    See identical proteins and their annotated locations for NP_001273080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC103590, AK315962
    Consensus CDS
    CCDS65787.1
    UniProtKB/Swiss-Prot
    O95861
    UniProtKB/TrEMBL
    B7Z9J7
    Related
    ENSP00000444398.1, ENST00000544404.5
    Conserved Domains (1) summary
    cd01640
    Location:1242
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  4. NM_006085.6NP_006076.4  3'(2'),5'-bisphosphate nucleotidase 1 isoform 1

    See identical proteins and their annotated locations for NP_006076.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC103590, AK291943
    Consensus CDS
    CCDS41469.1
    UniProtKB/Swiss-Prot
    O95861
    UniProtKB/TrEMBL
    V9HWF9
    Related
    ENSP00000318852.7, ENST00000322067.12
    Conserved Domains (1) summary
    cd01640
    Location:11297
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    220057482..220089916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509064.2XP_011507366.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X7

    Conserved Domains (1) summary
    cd01640
    Location:1221
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  2. XM_006711114.3XP_006711177.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X3

    See identical proteins and their annotated locations for XP_006711177.1

    Conserved Domains (1) summary
    cd01640
    Location:11276
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  3. XM_017000046.1XP_016855535.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X11

  4. XM_011509063.2XP_011507365.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X5

    Conserved Domains (1) summary
    cd01640
    Location:1257
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  5. XM_005273005.4XP_005273062.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X6

    See identical proteins and their annotated locations for XP_005273062.1

    Conserved Domains (1) summary
    cd01640
    Location:11231
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  6. XM_005272999.5XP_005273056.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005273056.1

    Conserved Domains (1) summary
    cd01640
    Location:11312
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  7. XM_017000044.1XP_016855533.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X9

  8. XM_017000043.1XP_016855532.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X4

    UniProtKB/Swiss-Prot
    O95861
    Conserved Domains (1) summary
    cd01640
    Location:11261
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  9. XM_005273000.5XP_005273057.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X2

    See identical proteins and their annotated locations for XP_005273057.1

    UniProtKB/Swiss-Prot
    O95861
    UniProtKB/TrEMBL
    V9HWF9
    Conserved Domains (1) summary
    cd01640
    Location:11297
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
  10. XM_005273004.3XP_005273061.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X6

    See identical proteins and their annotated locations for XP_005273061.1

    Conserved Domains (1) summary
    cd01640
    Location:11231
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  11. XM_005272998.3XP_005273055.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005273055.1

    Related
    ENSP00000346862.3, ENST00000354807.7
    Conserved Domains (1) summary
    cd01640
    Location:11312
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
  12. XM_017000045.2XP_016855534.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X10

  13. XM_011509065.3XP_011507367.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X8

    Conserved Domains (1) summary
    cl00289
    Location:11157
    FIG; FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in ...
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