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Raf1 Raf-1 proto-oncogene, serine/threonine kinase [ Nannospalax galili (Upper Galilee mountains blind mole rat) ]

Gene ID: 103751450, updated on 11-Mar-2024

Summary

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Gene symbol
Raf1
Gene description
Raf-1 proto-oncogene, serine/threonine kinase
See related
Ensembl:ENSNGAG00000019548
Gene type
protein coding
RefSeq status
MODEL
Organism
Nannospalax galili
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Spalacidae; Spalacinae; Nannospalax
Orthologs
human mouse all
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Genomic context

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See Raf1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
19
Annotation release Status Assembly Chr Location
102 current S.galili_v1.0 (GCF_000622305.1) Unplaced Scaffold NW_008357033.1 (6896403..6961905, complement)

NW_008357033.1Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene makorin ring finger protein 2 Neighboring gene transmembrane protein 258 pseudogene Neighboring gene transmembrane protein 40

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_008357033 Unplaced Scaffold Reference S.galili_v1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patterns. Malik A, et al. PLoS One, 2011. PMID 21857902, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAF proto-oncogene serine/threonine-protein kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nannospalax galili Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference S.galili_v1.0 Primary Assembly

Genomic

  1. NW_008357033.1 Reference S.galili_v1.0 Primary Assembly

    Range
    6896403..6961905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008854911.2 → XP_008853133.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C6RLN2, A0A8C6WAP7
    Related
    ENSNGAP00000019879.1, ENSNGAT00000025544.1
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    pfam00130
    Location:139 → 184
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_029557078.1 → XP_029412938.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8C6WAP7
    Conserved Domains (3) summary
    cd14149
    Location:261 → 543
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:64 → 109
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl28922
    Location:1 → 56
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_029557077.1 → XP_029412937.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C6RLN2, A0A8C6WAP7
    Related
    ENSNGAP00000019890.1, ENSNGAT00000025555.1
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    pfam00130
    Location:139 → 184
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
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