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Tbc1d10a TBC1 domain family, member 10a [ Mus musculus (house mouse) ]

Gene ID: 103724, updated on 11-Apr-2024

Summary

Official Symbol
Tbc1d10aprovided by MGI
Official Full Name
TBC1 domain family, member 10aprovided by MGI
Primary source
MGI:MGI:2144164
See related
Ensembl:ENSMUSG00000034412 AllianceGenome:MGI:2144164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EPI64; Tbc1d10; mFLJ00288
Summary
Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in intracellular protein transport; positive regulation of hydrolase activity; and retrograde transport, endosome to Golgi. Predicted to be located in plasma membrane. Is expressed in renal calyx and vibrissa. Orthologous to human TBC1D10A (TBC1 domain family member 10A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 13.5), bladder adult (RPKM 11.6) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 A1; 11 2.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4136852..4167407)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4186833..4215507)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 215 Neighboring gene microRNA 3060 Neighboring gene coiled-coil domain containing 157 Neighboring gene splicing factor 3a, subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E727 Neighboring gene STARR-positive B cell enhancer ABC_E2978 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene predicted gene 11956 Neighboring gene oncostatin M

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ00288

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TBC1 domain family member 10A
Names
EBP50-PDX interactor of 64 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134023.2NP_598784.1  TBC1 domain family member 10A

    See identical proteins and their annotated locations for NP_598784.1

    Status: VALIDATED

    Source sequence(s)
    AL807825
    Consensus CDS
    CCDS56756.1
    UniProtKB/Swiss-Prot
    P58802
    UniProtKB/TrEMBL
    Q3US32
    Related
    ENSMUSP00000136453.2, ENSMUST00000180088.2
    Conserved Domains (1) summary
    smart00164
    Location:110313
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4136852..4167407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)