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Tmed4 transmembrane p24 trafficking protein 4 [ Mus musculus (house mouse) ]

Gene ID: 103694, updated on 9-May-2024

Summary

Official Symbol
Tmed4provided by MGI
Official Full Name
transmembrane p24 trafficking protein 4provided by MGI
Primary source
MGI:MGI:1915070
See related
Ensembl:ENSMUSG00000004394 AllianceGenome:MGI:1915070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110014L17Rik
Summary
Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to act upstream of or within protein transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in central nervous system and retina. Orthologous to human TMED4 (transmembrane p24 trafficking protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 106.7), duodenum adult (RPKM 74.9) and 28 other tissues See more
Orthologs
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Genomic context

See Tmed4 in Genome Data Viewer
Location:
11 A1; 11 3.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6220714..6224837, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6270714..6274837, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28456 Neighboring gene predicted gene 11401 Neighboring gene DEAD box helicase 56 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6167755-6167938 Neighboring gene STARR-positive B cell enhancer ABC_E9136 Neighboring gene STARR-positive B cell enhancer ABC_E6948 Neighboring gene STARR-positive B cell enhancer ABC_E2347 Neighboring gene predicted gene, 46270 Neighboring gene oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane emp24 domain-containing protein 4
Names
ERS25
endoplasmic reticulum stress-response protein 25
p24 family protein alpha-3
p24alpha3
p26
transmembrane emp24 protein transport domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134020.1NP_598781.1  transmembrane emp24 domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_598781.1

    Status: PROVISIONAL

    Source sequence(s)
    BC023041
    Consensus CDS
    CCDS24415.1
    UniProtKB/Swiss-Prot
    Q3TY55, Q8R1V4
    Related
    ENSMUSP00000004508.7, ENSMUST00000004508.13
    Conserved Domains (1) summary
    pfam01105
    Location:29222
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6220714..6224837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)