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Xpo1 exportin 1 [ Mus musculus (house mouse) ]

Gene ID: 103573, updated on 5-Jan-2023

Summary

Official Symbol
Xpo1provided by MGI
Official Full Name
exportin 1provided by MGI
Primary source
MGI:MGI:2144013
See related
Ensembl:ENSMUSG00000020290 AllianceGenome:MGI:2144013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crm1; Exp1
Summary
Enables nuclear export signal receptor activity. Acts upstream of or within several processes, including protein export from nucleus; regulation of centrosome duplication; and regulation of protein export from nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; nervous system; respiratory system; and sensory organ. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 31.7), limb E14.5 (RPKM 25.4) and 23 other tissues See more
Orthologs
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Genomic context

See Xpo1 in Genome Data Viewer
Location:
11; 11 A3.2
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23205909..23247597)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23255909..23297597)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700061J23 gene Neighboring gene predicted gene, 24398 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene predicted gene, 22753 Neighboring gene AHA1, activator of heat shock protein ATPase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear export signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear export signal receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal large subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal small subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
exportin-1
Names
chromosome region maintenance 1 protein homolog
exportin 1, CRM1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035226.1NP_001030303.1  exportin-1

    See identical proteins and their annotated locations for NP_001030303.1

    Status: VALIDATED

    Source sequence(s)
    AK037196, BC062912
    Consensus CDS
    CCDS24475.1
    UniProtKB/Swiss-Prot
    Q6P5F9
    UniProtKB/TrEMBL
    A0A8C6IKA1, Q8BYY5
    Related
    ENSMUSP00000105178.2, ENSMUST00000109551.8
    Conserved Domains (1) summary
    COG5101
    Location:151044
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
  2. NM_001412406.1NP_001399335.1  exportin-1

    Status: VALIDATED

    Source sequence(s)
    AL772359
    UniProtKB/Swiss-Prot
    Q6P5F9
    UniProtKB/TrEMBL
    A0A8C6IKA1
  3. NM_001412407.1NP_001399336.1  exportin-1

    Status: VALIDATED

    Source sequence(s)
    AL772359
    UniProtKB/Swiss-Prot
    Q6P5F9
    UniProtKB/TrEMBL
    A0A8C6IKA1
  4. NM_001412408.1NP_001399337.1  exportin-1

    Status: VALIDATED

    Source sequence(s)
    AL772359
    UniProtKB/Swiss-Prot
    Q6P5F9
    UniProtKB/TrEMBL
    A0A8C6IKA1
  5. NM_134014.3NP_598775.2  exportin-1

    See identical proteins and their annotated locations for NP_598775.2

    Status: VALIDATED

    Source sequence(s)
    AK037196, BC062912, CD347786
    Consensus CDS
    CCDS24475.1
    UniProtKB/Swiss-Prot
    Q6P5F9
    UniProtKB/TrEMBL
    A0A8C6IKA1, Q8BYY5
    Related
    ENSMUSP00000020538.7, ENSMUST00000020538.13
    Conserved Domains (1) summary
    COG5101
    Location:151044
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23205909..23247597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514430.3XP_006514493.1  exportin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q6P5F9
    Related
    ENSMUSP00000099933.2, ENSMUST00000102869.8
    Conserved Domains (1) summary
    COG5101
    Location:151044
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
  2. XM_017314209.3XP_017169698.1  exportin-1 isoform X3

    Conserved Domains (1) summary
    COG5101
    Location:1913
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
  3. XM_017314208.3XP_017169697.1  exportin-1 isoform X2

    Conserved Domains (1) summary
    COG5101
    Location:10978
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]