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Mgat4b mannoside acetylglucosaminyltransferase 4, isoenzyme B [ Mus musculus (house mouse) ]

Gene ID: 103534, updated on 26-Sep-2022

Summary

Official Symbol
Mgat4bprovided by MGI
Official Full Name
mannoside acetylglucosaminyltransferase 4, isoenzyme Bprovided by MGI
Primary source
MGI:MGI:2143974
See related
Ensembl:ENSMUSG00000036620 AllianceGenome:MGI:2143974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GnTIVb
Summary
Enables acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including adrenal gland; nervous system; nose; respiratory system; and urinary system. Orthologous to human MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 90.9), adrenal adult (RPKM 83.9) and 28 other tissues See more
Orthologs
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Genomic context

See Mgat4b in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50116162..50125930)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50225335..50235103)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sequestosome 1 Neighboring gene predicted gene, 36556 Neighboring gene microRNA 6919 Neighboring gene leukotriene C4 synthase Neighboring gene mastermind like transcriptional coactivator 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein N-linked glycosylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Names
GlcNAc-T IVb
N-acetylglucosaminyltransferase IVb
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb
gnT-IVb
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B
NP_666038.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145926.3NP_666038.3  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B precursor

    See identical proteins and their annotated locations for NP_666038.3

    Status: VALIDATED

    Source sequence(s)
    AL627187, BY729920, CX205743, CX206051, W66623
    Consensus CDS
    CCDS24630.1
    UniProtKB/Swiss-Prot
    Q812F8, Q8R0L4
    UniProtKB/TrEMBL
    A0A6P5QQ87, A0A8C6GSB1
    Related
    ENSMUSP00000043346.8, ENSMUST00000041725.14
    Conserved Domains (2) summary
    pfam04666
    Location:110387
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:294314
    PGAP4-like; putative TM2 helix [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50116162..50125930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)