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TRIM22 tripartite motif containing 22 [ Homo sapiens (human) ]

Gene ID: 10346, updated on 1-Aug-2020

Summary

Official Symbol
TRIM22provided by HGNC
Official Full Name
tripartite motif containing 22provided by HGNC
Primary source
HGNC:HGNC:16379
See related
Ensembl:ENSG00000132274 MIM:606559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF94; STAF50; GPSTAF50
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Expression
Broad expression in spleen (RPKM 83.9), lymph node (RPKM 70.5) and 24 other tissues See more
Orthologs

Genomic context

See TRIM22 in Genome Data Viewer
Location:
11p15.4
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (5689790..5710863)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5710817..5732093)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TRIM6-TRIM34 readthrough Neighboring gene tripartite motif containing 5 Neighboring gene tripartite motif containing 34 Neighboring gene uncharacterized LOC107984302 Neighboring gene olfactory receptor family 52 subfamily U member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily P member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily N member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of tripartite motif containing 22 (TRIM22) in human B cells PubMed
env HIV-1 gp120-treated vaginal epithelial cells show upregulation of tripartite motif containing 22 (TRIM22) expression as compared to untreated control PubMed
Pr55(Gag) gag TRIM22 changes the sub-cellular localization of Gag protein. The catalytic cysteine residues C15 and C18 are important for the antiviral effects of TRIM22 PubMed
gag IFN-beta-induced expression of TRIM22 restricts HIV-1 replication. TRIM22 inhibits the budding of HIV-1 Gag-only particles PubMed
gag A direct or indirect interaction of TRIM21 with HIV-1 Gag induces encapsidation of TRIM21 into virus particles, leading to slightly reduced virus titers PubMed
Tat tat HIV-1 and the viral protein Tat modulate the expression of tripartite motif-containing 22 (TRIM22; STAF50) in immature dendritic cells and monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Staf50, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
tat Staf-50 downregulates transcription directed by the HIV-1 LTR promoter, suggesting an inhibition of HIV-1 Tat function PubMed
tat Overexpression of Staf50, which is known to repress the activity of HIV-1 Tat, inhibits HIV-1 infection between 50% and 90% in 293 T CD4/CCR5 cells as well as in monocyte-derived macrophages (MAC) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: OR56B1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to virus TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cajal body IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM22
Names
50 kDa-stimulated trans-acting factor
RING finger protein 94
RING-type E3 ubiquitin transferase TRIM22
staf-50
stimulated trans-acting factor (50 kDa)
tripartite binding motif 22
tripartite motif protein TRIM22
tripartite motif-containing protein 22
NP_001186502.1
NP_006065.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199573.2NP_001186502.1  E3 ubiquitin-protein ligase TRIM22 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL360190, BC022281, BC035582, DC364428, X82200
    UniProtKB/Swiss-Prot
    Q8IYM9
    UniProtKB/TrEMBL
    B4DQS5
    Conserved Domains (4) summary
    smart00336
    Location:92133
    BBOX; B-Box-type zinc finger
    pfam14942
    Location:133203
    Muted; Organelle biogenesis, Muted-like protein
    cd15824
    Location:295492
    SPRY_PRY_TRIM22; PRY/SPRY domain in tripartite motif-containing protein 22 (TRIM22), also known as RING finger protein 94 (RNF94) or Stimulated trans-acting factor of 50 kDa (STAF50)
    cl17238
    Location:1559
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_006074.5NP_006065.2  E3 ubiquitin-protein ligase TRIM22 isoform 1

    See identical proteins and their annotated locations for NP_006065.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL360190, BC022281, BC035582, DC364428
    Consensus CDS
    CCDS41612.1
    UniProtKB/Swiss-Prot
    Q8IYM9
    UniProtKB/TrEMBL
    B4DQS5
    Related
    ENSP00000369299.3, ENST00000379965.8
    Conserved Domains (4) summary
    smart00336
    Location:92133
    BBOX; B-Box-type zinc finger
    pfam15035
    Location:129205
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cd15824
    Location:299496
    SPRY_PRY_TRIM22; PRY/SPRY domain in tripartite motif-containing protein 22 (TRIM22), also known as RING finger protein 94 (RNF94) or Stimulated trans-acting factor of 50 kDa (STAF50)
    cl17238
    Location:1559
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    5689790..5710863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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