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TFG trafficking from ER to golgi regulator [ Homo sapiens (human) ]

Gene ID: 10342, updated on 1-Jun-2020

Summary

Official Symbol
TFGprovided by HGNC
Official Full Name
trafficking from ER to golgi regulatorprovided by HGNC
Primary source
HGNC:HGNC:11758
See related
Ensembl:ENSG00000114354 MIM:602498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF6; HMSNP; SPG57; TRKT3
Summary
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in duodenum (RPKM 35.2), placenta (RPKM 33.3) and 25 other tissues See more
Orthologs

Genomic context

See TFG in Genome Data Viewer
Location:
3q12.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (100709290..100748967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100428128..100467811)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 45A Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene ABI family member 3 binding protein Neighboring gene abraxas 1, BRCA1 A complex subunit pseudogene Neighboring gene RNA, U6 small nuclear 865, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein TFG
Names
TRK-fused
TRK-fused gene protein
TRKT3 oncogene

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027821.2 RefSeqGene

    Range
    5001..44678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007565.2NP_001007566.1  protein TFG isoform 1

    See identical proteins and their annotated locations for NP_001007566.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC069223, BQ008360, DA704111
    Consensus CDS
    CCDS2939.1
    UniProtKB/Swiss-Prot
    Q92734
    Related
    ENSP00000419960.1, ENST00000490574.5
    Conserved Domains (2) summary
    cd06401
    Location:1191
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:325400
    dnaA; chromosomal replication initiation protein; Provisional
  2. NM_001195478.1NP_001182407.1  protein TFG isoform 1

    See identical proteins and their annotated locations for NP_001182407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    BC001483, BQ008360
    Consensus CDS
    CCDS2939.1
    UniProtKB/Swiss-Prot
    Q92734
    Conserved Domains (2) summary
    cd06401
    Location:1191
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:325400
    dnaA; chromosomal replication initiation protein; Provisional
  3. NM_001195479.1NP_001182408.1  protein TFG isoform 2

    See identical proteins and their annotated locations for NP_001182408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) utilizes an alternate splice site in the coding region, compared to variant 1. Isoform 2 is shorter than isoform 1.
    Source sequence(s)
    AC069223, BC009241, BC041600, BQ008360
    Consensus CDS
    CCDS56266.1
    UniProtKB/Swiss-Prot
    Q92734
    UniProtKB/TrEMBL
    Q05BK6
    Related
    ENSP00000417952.1, ENST00000476228.5
    Conserved Domains (2) summary
    cd06401
    Location:1191
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:321396
    dnaA; chromosomal replication initiation protein; Provisional
  4. NM_006070.6NP_006061.2  protein TFG isoform 1

    See identical proteins and their annotated locations for NP_006061.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK093456, BC009241
    Consensus CDS
    CCDS2939.1
    UniProtKB/Swiss-Prot
    Q92734
    Related
    ENSP00000240851.4, ENST00000240851.9
    Conserved Domains (2) summary
    cd06401
    Location:1191
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:325400
    dnaA; chromosomal replication initiation protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    100709290..100748967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247066.2XP_005247123.1  protein TFG isoform X2

    See identical proteins and their annotated locations for XP_005247123.1

    UniProtKB/Swiss-Prot
    Q92734
    Related
    ENSP00000397182.2, ENST00000418917.6
    Conserved Domains (2) summary
    cd06401
    Location:1191
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:321396
    dnaA; chromosomal replication initiation protein; Provisional
  2. XM_006713472.1XP_006713535.1  protein TFG isoform X1

    See identical proteins and their annotated locations for XP_006713535.1

    UniProtKB/Swiss-Prot
    Q92734
    Conserved Domains (2) summary
    cd06401
    Location:1191
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:325400
    dnaA; chromosomal replication initiation protein; Provisional
  3. XM_017005527.1XP_016861016.1  protein TFG isoform X2

    UniProtKB/Swiss-Prot
    Q92734
    Conserved Domains (2) summary
    cd06401
    Location:1191
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:321396
    dnaA; chromosomal replication initiation protein; Provisional
  4. XM_011512334.1XP_011510636.1  protein TFG isoform X1

    See identical proteins and their annotated locations for XP_011510636.1

    UniProtKB/Swiss-Prot
    Q92734
    Conserved Domains (2) summary
    cd06401
    Location:1191
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:325400
    dnaA; chromosomal replication initiation protein; Provisional
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