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TLR6 toll like receptor 6 [ Homo sapiens (human) ]

Gene ID: 10333, updated on 4-Jun-2020

Summary

Official Symbol
TLR6provided by HGNC
Official Full Name
toll like receptor 6provided by HGNC
Primary source
HGNC:HGNC:16711
See related
Ensembl:ENSG00000174130 MIM:605403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD286
Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
Expression
Broad expression in appendix (RPKM 4.9), spleen (RPKM 4.1) and 20 other tissues See more
Orthologs

Genomic context

See TLR6 in Genome Data Viewer
Location:
4p14
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (38823680..38857767, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38825325..38858438, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene toll like receptor 10 Neighboring gene Sharpr-MPRA regulatory region 13104 Neighboring gene toll like receptor 1 Neighboring gene family with sequence similarity 114 member A1 Neighboring gene microRNA 574 Neighboring gene transmembrane protein 156

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
Identification of genetic loci associated with Helicobacter pylori serologic status.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of toll-like receptor 6 (TLR6) in human B cells PubMed
Envelope transmembrane glycoprotein gp41 env Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 gp41 increases IL-8 production PubMed
env The HIV-1 gp41 transmembrane domain (TMD) inhibits the interaction between the TMDs of TLR2 and TLR6 in vitro PubMed
capsid gag Exposure of the TLR2 transgene cell line, HEK293-TLR2/6, to HIV-1 CA (p24) increases IL-8 production BUT NOT in the TLR2 transgene cell lines, TZM-bl-2 and HEK293-TLR2/1 PubMed
matrix gag Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 MA (p17) increases the production of IL-8 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
Toll-like receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Toll-like receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding IC
Inferred by Curator
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopeptide binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
TRIF-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
cell activation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to bacterial lipopeptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to diacyl bacterial lipopeptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidised low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
detection of diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-8 secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of toll-like receptor 2 signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
nitric oxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oxidative stress-induced neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
toll-like receptor 6 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Toll-like receptor 2-Toll-like receptor 6 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
toll-like receptor 6
NP_006059.2
XP_005262694.1
XP_011511915.1
XP_011511916.1
XP_024309641.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028087.1 RefSeqGene

    Range
    5001..38114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006068.4NP_006059.2  toll-like receptor 6 precursor

    See identical proteins and their annotated locations for NP_006059.2

    Status: REVIEWED

    Source sequence(s)
    AC108044, AK313618
    Consensus CDS
    CCDS3446.1
    UniProtKB/Swiss-Prot
    Q9Y2C9
    UniProtKB/TrEMBL
    B2R933
    Related
    ENSP00000389600.2, ENST00000436693.6
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    38823680..38857767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513614.3XP_011511916.1  toll-like receptor 6 isoform X1

    See identical proteins and their annotated locations for XP_011511916.1

    UniProtKB/Swiss-Prot
    Q9Y2C9
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  2. XM_005262637.5XP_005262694.1  toll-like receptor 6 isoform X1

    See identical proteins and their annotated locations for XP_005262694.1

    UniProtKB/Swiss-Prot
    Q9Y2C9
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  3. XM_011513613.3XP_011511915.1  toll-like receptor 6 isoform X1

    See identical proteins and their annotated locations for XP_011511915.1

    UniProtKB/Swiss-Prot
    Q9Y2C9
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  4. XM_024453873.1XP_024309641.1  toll-like receptor 6 isoform X1

    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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