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TLR6 toll like receptor 6 [ Homo sapiens (human) ]

Gene ID: 10333, updated on 4-Sep-2021

Summary

Official Symbol
TLR6provided by HGNC
Official Full Name
toll like receptor 6provided by HGNC
Primary source
HGNC:HGNC:16711
See related
Ensembl:ENSG00000174130 MIM:605403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD286
Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
Expression
Broad expression in appendix (RPKM 4.9), spleen (RPKM 4.1) and 20 other tissues See more
Orthologs
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Genomic context

See TLR6 in Genome Data Viewer
Location:
4p14
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (38822897..38857755, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38825325..38858438, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene toll like receptor 10 Neighboring gene Sharpr-MPRA regulatory region 13104 Neighboring gene toll like receptor 1 Neighboring gene family with sequence similarity 114 member A1 Neighboring gene microRNA 574 Neighboring gene transmembrane protein 156

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
Identification of genetic loci associated with Helicobacter pylori serologic status.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of toll-like receptor 6 (TLR6) in human B cells PubMed
Envelope transmembrane glycoprotein gp41 env Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 gp41 increases IL-8 production PubMed
env The HIV-1 gp41 transmembrane domain (TMD) inhibits the interaction between the TMDs of TLR2 and TLR6 in vitro PubMed
capsid gag Exposure of the TLR2 transgene cell line, HEK293-TLR2/6, to HIV-1 CA (p24) increases IL-8 production BUT NOT in the TLR2 transgene cell lines, TZM-bl-2 and HEK293-TLR2/1 PubMed
matrix gag Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 MA (p17) increases the production of IL-8 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
enables Toll-like receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Toll-like receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables amyloid-beta binding IC
Inferred by Curator
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipopeptide binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in TRIF-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in activation of NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to bacterial lipopeptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to diacyl bacterial lipopeptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within detection of diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-8 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of toll-like receptor 2 signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nitric oxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of oxidative stress-induced neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in toll-like receptor 6 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
toll-like receptor 6
NP_001381482.1
NP_006059.2
XP_005262694.1
XP_011511915.1
XP_024309641.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028087.1 RefSeqGene

    Range
    5001..38114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394553.1NP_001381482.1  toll-like receptor 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC108044
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:43304
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
  2. NM_006068.5NP_006059.2  toll-like receptor 6 precursor

    See identical proteins and their annotated locations for NP_006059.2

    Status: REVIEWED

    Source sequence(s)
    AC108044
    Consensus CDS
    CCDS3446.1
    UniProtKB/Swiss-Prot
    Q9Y2C9
    UniProtKB/TrEMBL
    B2R933
    Related
    ENSP00000389600.2, ENST00000436693.6
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:43304
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    38822897..38857755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262637.5XP_005262694.1  toll-like receptor 6 isoform X1

    See identical proteins and their annotated locations for XP_005262694.1

    UniProtKB/Swiss-Prot
    Q9Y2C9
    Related
    ENSP00000371376.1, ENST00000381950.1
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:43304
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
  2. XM_011513613.3XP_011511915.1  toll-like receptor 6 isoform X1

    See identical proteins and their annotated locations for XP_011511915.1

    UniProtKB/Swiss-Prot
    Q9Y2C9
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:43304
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
  3. XM_024453873.1XP_024309641.1  toll-like receptor 6 isoform X1

    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:43304
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
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