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TLR6 toll like receptor 6 [ Homo sapiens (human) ]

Gene ID: 10333, updated on 12-Aug-2018

Summary

Official Symbol
TLR6provided by HGNC
Official Full Name
toll like receptor 6provided by HGNC
Primary source
HGNC:HGNC:16711
See related
Ensembl:ENSG00000174130 MIM:605403; Vega:OTTHUMG00000128579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD286
Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
Expression
Broad expression in appendix (RPKM 4.9), spleen (RPKM 4.1) and 20 other tissues See more
Orthologs

Genomic context

See TLR6 in Genome Data Viewer
Location:
4p14
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (38823680..38857767, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38825325..38858438, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene toll like receptor 10 Neighboring gene toll like receptor 1 Neighboring gene family with sequence similarity 114 member A1 Neighboring gene microRNA 574 Neighboring gene transmembrane protein 156

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
Identification of genetic loci associated with Helicobacter pylori serologic status.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of toll-like receptor 6 (TLR6) in human B cells PubMed
Envelope transmembrane glycoprotein gp41 env Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 gp41 increases IL-8 production PubMed
env The HIV-1 gp41 transmembrane domain (TMD) inhibits the interaction between the TMDs of TLR2 and TLR6 in vitro PubMed
capsid gag Exposure of the TLR2 transgene cell line, HEK293-TLR2/6, to HIV-1 CA (p24) increases IL-8 production BUT NOT in the TLR2 transgene cell lines, TZM-bl-2 and HEK293-TLR2/1 PubMed
matrix gag Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 MA (p17) increases the production of IL-8 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
    Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with the TLR signaling cascade, organism-specific biosystem (from REACTOME)
    Diseases associated with the TLR signaling cascade, organism-specific biosystemToll like receptors (TLRs) are sensors of the innate immune system that detect danger signals derived from pathogens (pathogen-associated molecular patterns - PAMP) or damaged cells (damage-associate...
  • Diseases of Immune System, organism-specific biosystem (from REACTOME)
    Diseases of Immune System, organism-specific biosystemThe immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may prese...
  • ER-Phagosome pathway, organism-specific biosystem (from REACTOME)
    ER-Phagosome pathway, organism-specific biosystemThe other TAP-dependent cross-presentation mechanism in phagocytes is the endoplasmic reticulum (ER)-phagosome model. Desjardins proposed that ER is recruited to the cell surface, where it fuses wit...
  • IRAK4 deficiency (TLR2/4), organism-specific biosystem (from REACTOME)
    IRAK4 deficiency (TLR2/4), organism-specific biosystemInterleukin-1 receptor-associated kinase 4 (IRAK4) is a serine/threonine kinase, that mediates activation of transcriptional factors such as NFkB and AP1 downstream of IL-1 receptors and all toll lik...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • MyD88 deficiency (TLR2/4), organism-specific biosystem (from REACTOME)
    MyD88 deficiency (TLR2/4), organism-specific biosystemMyeloid differentiation primary response (MyD88) is an adaptor protein that mediates intracellular signaling pathways evoked by all Toll-like receptors (TLRs) except for TLR3 and by several interleuk...
  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
    Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway
  • Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystem (from WikiPathways)
    Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystemThis pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 ...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Toll-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
    Toll-like Receptor Signaling, organism-specific biosystemThis pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflamma...
  • Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Toll-like Receptor Signaling Pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Toll-like receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Toll-like receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopeptide binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
TRIF-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
cell activation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to diacyl bacterial lipopeptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidised low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
detection of diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-8 secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of toll-like receptor 2 signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
nitric oxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of macrophage activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oxidative stress-induced neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
toll-like receptor 6 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Toll-like receptor 2-Toll-like receptor 6 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular IPI
Inferred from Physical Interaction
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028087.1 RefSeqGene

    Range
    5001..38114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006068.4NP_006059.2  toll-like receptor 6 precursor

    See identical proteins and their annotated locations for NP_006059.2

    Status: REVIEWED

    Source sequence(s)
    AC108044, AK313618
    Consensus CDS
    CCDS3446.1
    UniProtKB/Swiss-Prot
    Q9Y2C9
    UniProtKB/TrEMBL
    B2R933
    Related
    ENSP00000389600.2, ENST00000436693.6
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    38823680..38857767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513614.3XP_011511916.1  toll-like receptor 6 isoform X1

    See identical proteins and their annotated locations for XP_011511916.1

    UniProtKB/Swiss-Prot
    Q9Y2C9
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  2. XM_005262637.5XP_005262694.1  toll-like receptor 6 isoform X1

    See identical proteins and their annotated locations for XP_005262694.1

    UniProtKB/Swiss-Prot
    Q9Y2C9
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  3. XM_011513613.3XP_011511915.1  toll-like receptor 6 isoform X1

    See identical proteins and their annotated locations for XP_011511915.1

    UniProtKB/Swiss-Prot
    Q9Y2C9
    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  4. XM_024453873.1XP_024309641.1  toll-like receptor 6 isoform X1

    Conserved Domains (7) summary
    smart00082
    Location:529582
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:641780
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3653
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:76133
    LRR_8; Leucine rich repeat
    cl26018
    Location:43208
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:353565
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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