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CNPY2 canopy FGF signaling regulator 2 [ Homo sapiens (human) ]

Gene ID: 10330, updated on 21-Dec-2019

Summary

Official Symbol
CNPY2provided by HGNC
Official Full Name
canopy FGF signaling regulator 2provided by HGNC
Primary source
HGNC:HGNC:13529
See related
Ensembl:ENSG00000257727 MIM:605861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSAP; TMEM4; ZSIG9; HP10390
Expression
Ubiquitous expression in prostate (RPKM 22.5), adrenal (RPKM 21.4) and 25 other tissues See more
Orthologs

Genomic context

See CNPY2 in Genome Data Viewer
Location:
12q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56309844..56316348, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56704212..56710128, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene coenzyme Q10A Neighboring gene citrate synthase Neighboring gene uncharacterized LOC112268098 Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene interleukin 23 subunit alpha Neighboring gene signal transducer and activator of transcription 2 Neighboring gene RNA, U7 small nuclear 40 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CS

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of low-density lipoprotein particle receptor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein canopy homolog 2
Names
MIR-interacting saposin-like protein
putative secreted protein Zsig9
transmembrane protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190991.2NP_001177920.1  protein canopy homolog 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AA515271, BC001027, BF526446, DA833421
    UniProtKB/Swiss-Prot
    Q9Y2B0
    Conserved Domains (1) summary
    pfam11938
    Location:2764
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  2. NM_014255.7NP_055070.1  protein canopy homolog 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW293214, AY359102, BE699270, BE858097
    Consensus CDS
    CCDS8914.1
    UniProtKB/Swiss-Prot
    Q9Y2B0
    Related
    ENSP00000273308.4, ENST00000273308.9
    Conserved Domains (1) summary
    pfam11938
    Location:27165
    DUF3456; TLR4 regulator and MIR-interacting MSAP

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56309844..56316348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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