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CNPY2 canopy FGF signaling regulator 2 [ Homo sapiens (human) ]

Gene ID: 10330, updated on 6-Sep-2022

Summary

Official Symbol
CNPY2provided by HGNC
Official Full Name
canopy FGF signaling regulator 2provided by HGNC
Primary source
HGNC:HGNC:13529
See related
Ensembl:ENSG00000257727 MIM:605861; AllianceGenome:HGNC:13529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSAP; TMEM4; ZSIG9; HP10390
Summary
Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 22.5), adrenal (RPKM 21.4) and 25 other tissues See more
Orthologs
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Genomic context

See CNPY2 in Genome Data Viewer
Location:
12q13.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56309844..56316346, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56277503..56283991, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56703628..56710130, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene coenzyme Q10A Neighboring gene citrate synthase Neighboring gene CNPY2 antisense RNA 1 Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene interleukin 23 subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CS

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of positive regulation of low-density lipoprotein receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of regulation of low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein canopy homolog 2
Names
MIR-interacting saposin-like protein
putative secreted protein Zsig9
transmembrane protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190991.3NP_001177920.1  protein canopy homolog 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AA515271, BC001027, BF526446, DA833421
    UniProtKB/Swiss-Prot
    Q9Y2B0
    Conserved Domains (1) summary
    pfam11938
    Location:2764
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  2. NM_014255.7NP_055070.1  protein canopy homolog 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW293214, AY359102, BE699270, BE858097
    Consensus CDS
    CCDS8914.1
    UniProtKB/Swiss-Prot
    Q9UHE9, Q9Y2B0
    Related
    ENSP00000273308.4, ENST00000273308.9
    Conserved Domains (1) summary
    pfam11938
    Location:27165
    DUF3456; TLR4 regulator and MIR-interacting MSAP

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56309844..56316346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56277503..56283991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)