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AKR1A1 aldo-keto reductase family 1 member A1 [ Homo sapiens (human) ]

Gene ID: 10327, updated on 25-Nov-2021

Summary

Official Symbol
AKR1A1provided by HGNC
Official Full Name
aldo-keto reductase family 1 member A1provided by HGNC
Primary source
HGNC:HGNC:380
See related
Ensembl:ENSG00000117448 MIM:103830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALR; ARM; DD3; ALDR1; HEL-S-6
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in kidney (RPKM 113.8), duodenum (RPKM 66.6) and 25 other tissues See more
Orthologs
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Genomic context

See AKR1A1 in Genome Data Viewer
Location:
1p34.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (45550779..45570051)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46016498..46035721)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene metabolism of cobalamin associated C Neighboring gene peroxiredoxin 1 Neighboring gene high mobility group box 1 pseudogene 48 Neighboring gene nuclear autoantigenic sperm protein Neighboring gene coiled-coil domain containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1380, MGC12529

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-threo-aldose 1-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-glucuronate reductase activity EXP
Inferred from Experiment
more info
PubMed 
enables L-glucuronate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables NAD-retinol dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aldo-keto reductase (NADP) activity TAS
Traceable Author Statement
more info
 
enables allyl-alcohol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables glucuronolactone reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycerol dehydrogenase [NADP+] activity IEA
Inferred from Electronic Annotation
more info
 
enables methylglyoxal reductase (NADPH-dependent, acetol producing) IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in D-glucuronate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-ascorbic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in aldehyde catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular detoxification of aldehyde ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in daunorubicin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in doxorubicin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucuronate catabolic process to xylulose 5-phosphate TAS
Traceable Author Statement
more info
 
involved_in glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aldo-keto reductase family 1 member A1
Names
HEL-S-165mP
alcohol dehydrogenase
aldehyde reductase
dihydrodiol dehydrogenase 3
epididymis secretory protein Li 6
epididymis secretory sperm binding protein Li 165mP
glucuronate reductase
glucuronolactone reductase
NP_001189342.1
NP_001189343.1
NP_006057.1
NP_697021.1
XP_011538793.1
XP_011538794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202413.2NP_001189342.1  aldo-keto reductase family 1 member A1

    See identical proteins and their annotated locations for NP_001189342.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AU142853, BI549149, BT007003, BU631634
    Consensus CDS
    CCDS523.1
    UniProtKB/Swiss-Prot
    P14550
    UniProtKB/TrEMBL
    V9HWI0
    Related
    ENSP00000480713.1, ENST00000621846.4
    Conserved Domains (1) summary
    COG0656
    Location:6303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
  2. NM_001202414.2NP_001189343.1  aldo-keto reductase family 1 member A1

    See identical proteins and their annotated locations for NP_001189343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BI549149, BT007003, BU631634, CX788871
    Consensus CDS
    CCDS523.1
    UniProtKB/Swiss-Prot
    P14550
    UniProtKB/TrEMBL
    V9HWI0
    Conserved Domains (1) summary
    COG0656
    Location:6303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
  3. NM_006066.4NP_006057.1  aldo-keto reductase family 1 member A1

    See identical proteins and their annotated locations for NP_006057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    BC000670, BU631634, DA871469
    Consensus CDS
    CCDS523.1
    UniProtKB/Swiss-Prot
    P14550
    UniProtKB/TrEMBL
    V9HWI0
    Related
    ENSP00000361140.3, ENST00000372070.7
    Conserved Domains (1) summary
    COG0656
    Location:6303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
  4. NM_153326.3NP_697021.1  aldo-keto reductase family 1 member A1

    See identical proteins and their annotated locations for NP_697021.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BI549149, BT007003, BU631634, DA550374
    Consensus CDS
    CCDS523.1
    UniProtKB/Swiss-Prot
    P14550
    UniProtKB/TrEMBL
    V9HWI0
    Related
    ENSP00000312606.4, ENST00000351829.9
    Conserved Domains (1) summary
    COG0656
    Location:6303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    45550779..45570051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540492.2XP_011538794.1  aldo-keto reductase family 1 member A1 isoform X1

    See identical proteins and their annotated locations for XP_011538794.1

    Conserved Domains (1) summary
    cl00470
    Location:1201
    AKR_SF; Aldo-keto reductase (AKR) superfamily
  2. XM_011540491.2XP_011538793.1  aldo-keto reductase family 1 member A1 isoform X1

    See identical proteins and their annotated locations for XP_011538793.1

    Conserved Domains (1) summary
    cl00470
    Location:1201
    AKR_SF; Aldo-keto reductase (AKR) superfamily

RNA

  1. XR_001736909.1 RNA Sequence

  2. XR_001736908.2 RNA Sequence

  3. XR_002957622.1 RNA Sequence

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