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AKR1A1 aldo-keto reductase family 1 member A1 [ Homo sapiens (human) ]

Gene ID: 10327, updated on 2-Oct-2018

Summary

Official Symbol
AKR1A1provided by HGNC
Official Full Name
aldo-keto reductase family 1 member A1provided by HGNC
Primary source
HGNC:HGNC:380
See related
Ensembl:ENSG00000117448 MIM:103830; Vega:OTTHUMG00000007740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALR; ARM; DD3; ALDR1; HEL-S-6
Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in kidney (RPKM 113.8), duodenum (RPKM 66.6) and 25 other tissues See more
Orthologs

Genomic context

See AKR1A1 in Genome Data Viewer
Location:
1p34.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (45550779..45570051)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46016455..46035723)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene metabolism of cobalamin associated C Neighboring gene peroxiredoxin 1 Neighboring gene high mobility group box 1 pseudogene 48 Neighboring gene nuclear autoantigenic sperm protein Neighboring gene coiled-coil domain containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1380, MGC12529

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-glucuronate reductase activity EXP
Inferred from Experiment
more info
PubMed 
alcohol dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aldo-keto reductase (NADP) activity TAS
Traceable Author Statement
more info
 
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
D-glucuronate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-ascorbic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aldehyde catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular aldehyde metabolic process TAS
Traceable Author Statement
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
glucuronate catabolic process to xylulose 5-phosphate TAS
Traceable Author Statement
more info
 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alcohol dehydrogenase [NADP(+)]
Names
HEL-S-165mP
alcohol dehydrogenase
aldehyde reductase
dihydrodiol dehydrogenase 3
epididymis secretory protein Li 6
epididymis secretory sperm binding protein Li 165mP
NP_001189342.1
NP_001189343.1
NP_006057.1
NP_697021.1
XP_011538793.1
XP_011538794.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202413.1NP_001189342.1  alcohol dehydrogenase [NADP(+)]

    See identical proteins and their annotated locations for NP_001189342.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AU142853, BI549149, BT007003, BU631634
    Consensus CDS
    CCDS523.1
    UniProtKB/Swiss-Prot
    P14550
    UniProtKB/TrEMBL
    V9HWI0
    Related
    ENSP00000480713.1, ENST00000621846.4
    Conserved Domains (1) summary
    COG0656
    Location:6303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
  2. NM_001202414.1NP_001189343.1  alcohol dehydrogenase [NADP(+)]

    See identical proteins and their annotated locations for NP_001189343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BI549149, BT007003, BU631634, CX788871
    Consensus CDS
    CCDS523.1
    UniProtKB/Swiss-Prot
    P14550
    UniProtKB/TrEMBL
    V9HWI0
    Conserved Domains (1) summary
    COG0656
    Location:6303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
  3. NM_006066.3NP_006057.1  alcohol dehydrogenase [NADP(+)]

    See identical proteins and their annotated locations for NP_006057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    BC000670, BI549149, BU631634, DA871469
    Consensus CDS
    CCDS523.1
    UniProtKB/Swiss-Prot
    P14550
    UniProtKB/TrEMBL
    V9HWI0
    Related
    ENSP00000361140.3, OTTHUMP00000009240, ENST00000372070.7, OTTHUMT00000020851
    Conserved Domains (1) summary
    COG0656
    Location:6303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
  4. NM_153326.2NP_697021.1  alcohol dehydrogenase [NADP(+)]

    See identical proteins and their annotated locations for NP_697021.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BI549149, BT007003, BU631634, DA550374
    Consensus CDS
    CCDS523.1
    UniProtKB/Swiss-Prot
    P14550
    UniProtKB/TrEMBL
    V9HWI0
    Related
    ENSP00000312606.4, OTTHUMP00000009241, ENST00000351829.8, OTTHUMT00000020852
    Conserved Domains (1) summary
    COG0656
    Location:6303
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    45550779..45570051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540492.2XP_011538794.1  alcohol dehydrogenase [NADP(+)] isoform X1

    See identical proteins and their annotated locations for XP_011538794.1

    Conserved Domains (2) summary
    COG0656
    Location:1192
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:31180
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  2. XM_011540491.2XP_011538793.1  alcohol dehydrogenase [NADP(+)] isoform X1

    See identical proteins and their annotated locations for XP_011538793.1

    Conserved Domains (2) summary
    COG0656
    Location:1192
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:31180
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RNA

  1. XR_001736909.1 RNA Sequence

  2. XR_001736908.2 RNA Sequence

  3. XR_002957622.1 RNA Sequence

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