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SIRPB1 signal regulatory protein beta 1 [ Homo sapiens (human) ]

Gene ID: 10326, updated on 8-Dec-2018

Summary

Official Symbol
SIRPB1provided by HGNC
Official Full Name
signal regulatory protein beta 1provided by HGNC
Primary source
HGNC:HGNC:15928
See related
Ensembl:ENSG00000101307 MIM:603889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD172b; SIRP-BETA-1
Summary
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Expression
Broad expression in appendix (RPKM 6.6), bone marrow (RPKM 6.0) and 22 other tissues See more
Orthologs

Genomic context

See SIRPB1 in Genome Data Viewer
Location:
20p13
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (1564193..1620447, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1545029..1600720, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372499 Neighboring gene signal regulatory protein delta Neighboring gene uncharacterized LOC107985409 Neighboring gene SIRPG antisense RNA 1 Neighboring gene signal regulatory protein gamma Neighboring gene RNA, 7SL, cytoplasmic 561, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of signal-regulatory protein beta 1 (SIRPB1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
    Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26614, DKFZp686A05192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
signal-regulatory protein beta-1
Names
CD172 antigen-like family member B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083910.3NP_001077379.1  signal-regulatory protein beta-1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame coding exons in the 3' region compared to variant 1. The resulting isoform (2) lacks an internal segment compared to isoform 1.
    Source sequence(s)
    BC025286, BP268958, DA331023, DA761891
    Consensus CDS
    CCDS42850.1
    UniProtKB/Swiss-Prot
    O00241
    Related
    ENSP00000371016.3, ENST00000381603.7
    Conserved Domains (2) summary
    smart00410
    Location:40143
    IG_like; Immunoglobulin like
    pfam07686
    Location:37144
    V-set; Immunoglobulin V-set domain
  2. NM_001135844.3NP_001129316.1  signal-regulatory protein beta-1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001129316.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The encoded isoform (3) is the same length as isoform 1, but these isoforms differ in their amino acid sequences. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AL138804, AL592544, BM285386, BX537992, DA761891
    Consensus CDS
    CCDS46571.1
    UniProtKB/Swiss-Prot
    Q5TFQ8
    Related
    ENSP00000279477.7, ENST00000279477.11
    Conserved Domains (4) summary
    cd00098
    Location:265338
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:42143
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:40143
    IG_like; Immunoglobulin like
    cl11960
    Location:142253
    Ig; Immunoglobulin domain
  3. NM_001329157.1NP_001316086.1  signal-regulatory protein beta-1 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The encoded isoform (3) is the same length as isoform 1, but these isoforms differ in their amino acid sequences. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK289866, BM285386, DA761891, DA967881
    Consensus CDS
    CCDS46571.1
    UniProtKB/Swiss-Prot
    Q5TFQ8
    Related
    ENSP00000456826.1, ENST00000568365.1
    Conserved Domains (4) summary
    cd00098
    Location:265338
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:42143
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:40143
    IG_like; Immunoglobulin like
    cl11960
    Location:142253
    Ig; Immunoglobulin domain
  4. NM_001330639.1NP_001317568.1  signal-regulatory protein beta-1 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The encoded isoform (4) is shorter and has multiple differences compared to isoform 1.
    Source sequence(s)
    BC025286, BP268958, BP300244
    Consensus CDS
    CCDS82591.1
    UniProtKB/Swiss-Prot
    O00241
    UniProtKB/TrEMBL
    H9KV29
    Related
    ENSP00000262929.5, ENST00000262929.9
    Conserved Domains (2) summary
    smart00410
    Location:39142
    IG_like; Immunoglobulin like
    pfam07686
    Location:36143
    V-set; Immunoglobulin V-set domain
  5. NM_006065.4NP_006056.2  signal-regulatory protein beta-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006056.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Isoforms 1 and 3 are the same length but differ in their amino acid sequences.
    Source sequence(s)
    AL049634, BC025286, BM010247, BP268958, BP295274, DA331023, DA761891, Y10376
    Consensus CDS
    CCDS13019.1
    UniProtKB/Swiss-Prot
    O00241
    Related
    ENSP00000371018.4, ENST00000381605.8
    Conserved Domains (4) summary
    cd00098
    Location:265344
    IgC; Immunoglobulin Constant domain
    cd05772
    Location:142253
    IgC_SIRP; Signal-regulatory protein (SIRP) immunoglobulin-like domain
    smart00410
    Location:40143
    IG_like; Immunoglobulin like
    pfam07686
    Location:37144
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    1564193..1620447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027577.1XP_016883066.1  signal-regulatory protein beta-1 isoform X1

    UniProtKB/Swiss-Prot
    O00241
    Conserved Domains (4) summary
    cd00098
    Location:265344
    IgC; Immunoglobulin Constant domain
    cd05772
    Location:142253
    IgC_SIRP; Signal-regulatory protein (SIRP) immunoglobulin-like domain
    smart00410
    Location:40143
    IG_like; Immunoglobulin like
    pfam07686
    Location:37144
    V-set; Immunoglobulin V-set domain
  2. XM_005260643.3XP_005260700.1  signal-regulatory protein beta-1 isoform X6

    Conserved Domains (3) summary
    smart00410
    Location:39142
    IG_like; Immunoglobulin like
    pfam07686
    Location:36143
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:141249
    Ig; Immunoglobulin domain
  3. XM_005260641.3XP_005260698.1  signal-regulatory protein beta-1 isoform X2

    Conserved Domains (4) summary
    cd00098
    Location:264343
    IgC; Immunoglobulin Constant domain
    cd05772
    Location:141252
    IgC_SIRP; Signal-regulatory protein (SIRP) immunoglobulin-like domain
    smart00410
    Location:39142
    IG_like; Immunoglobulin like
    pfam07686
    Location:36143
    V-set; Immunoglobulin V-set domain
  4. XM_017027584.1XP_016883073.1  signal-regulatory protein beta-1 isoform X5

  5. XM_017027583.1XP_016883072.1  signal-regulatory protein beta-1 isoform X5

  6. XM_017027579.1XP_016883068.1  signal-regulatory protein beta-1 isoform X3

  7. XM_017027580.1XP_016883069.1  signal-regulatory protein beta-1 isoform X3

  8. XM_017027578.1XP_016883067.1  signal-regulatory protein beta-1 isoform X3

  9. XM_011529134.2XP_011527436.1  signal-regulatory protein beta-1 isoform X4

    Conserved Domains (4) summary
    cd00098
    Location:265338
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:42143
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:40143
    IG_like; Immunoglobulin like
    cl11960
    Location:142253
    Ig; Immunoglobulin domain

RNA

  1. XR_001754121.1 RNA Sequence

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