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RRAGB Ras related GTP binding B [ Homo sapiens (human) ]

Gene ID: 10325, updated on 23-Nov-2021

Summary

Official Symbol
RRAGBprovided by HGNC
Official Full Name
Ras related GTP binding Bprovided by HGNC
Primary source
HGNC:HGNC:19901
See related
Ensembl:ENSG00000083750 MIM:300725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAGB; bA465E19.1
Summary
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 5.3), thyroid (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See RRAGB in Genome Data Viewer
Location:
Xp11.21
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (55717747..55760209)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55744182..55785207)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X antigen family member 3-like Neighboring gene XAGE-4 protein Neighboring gene Kruppel like factor 8 Neighboring gene GOT2 pseudogene 6 Neighboring gene ribosomal protein L23a pseudogene 83

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of smoking behaviours among Bangladeshi adults.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Ras-related GTP binding B (RRAGB) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables guanyl ribonucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lysosomal membrane HDA PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related GTP-binding protein B
Names
GTP-binding protein ragB
rag B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354011.2NP_001340940.1  ras-related GTP-binding protein B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
    Conserved Domains (1) summary
    cd11384
    Location:4315
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
  2. NM_001354013.2NP_001340942.1  ras-related GTP-binding protein B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
    Conserved Domains (1) summary
    cd11384
    Location:4287
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
  3. NM_006064.5NP_006055.3  ras-related GTP-binding protein B short isoform

    See identical proteins and their annotated locations for NP_006055.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as RAGBs) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter isoform (2).
    Source sequence(s)
    BC034726, DB252202
    Consensus CDS
    CCDS14371.1
    UniProtKB/Swiss-Prot
    Q5VZM2
    Related
    ENSP00000364077.4, ENST00000374941.9
    Conserved Domains (1) summary
    cd11384
    Location:42325
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
  4. NM_016656.4NP_057740.2  ras-related GTP-binding protein B long isoform

    See identical proteins and their annotated locations for NP_057740.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as RAGBl) encodes the longest isoform (1).
    Source sequence(s)
    BC034726, DB252202, X90530
    Consensus CDS
    CCDS14372.1
    UniProtKB/Swiss-Prot
    Q5VZM2
    Related
    ENSP00000262850.7, ENST00000262850.7
    Conserved Domains (1) summary
    cd11384
    Location:42353
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

RNA

  1. NR_148683.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  2. NR_148684.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  3. NR_148685.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  4. NR_148686.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  5. NR_148687.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  6. NR_148688.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  7. NR_148689.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  8. NR_148690.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  9. NR_148691.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987
  10. NR_148692.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139277, AL159987

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    55717747..55760209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029218.2XP_016884707.1  ras-related GTP-binding protein B isoform X1

RNA

  1. XR_001755636.2 RNA Sequence

  2. XR_002958762.1 RNA Sequence

  3. XR_001755641.2 RNA Sequence

  4. XR_001755646.2 RNA Sequence

  5. XR_001755643.2 RNA Sequence

  6. XR_002958763.1 RNA Sequence

  7. XR_244464.4 RNA Sequence

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