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Csnk1g2 casein kinase 1, gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 103236, updated on 18-Apr-2024

Summary

Official Symbol
Csnk1g2provided by MGI
Official Full Name
casein kinase 1, gamma 2provided by MGI
Primary source
MGI:MGI:1920014
See related
Ensembl:ENSMUSG00000003345 AllianceGenome:MGI:1920014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810429I12Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in brain; genitourinary system; and skin. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 317.9), colon adult (RPKM 106.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 C1; 10 39.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80458465..80476605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80622676..80640771)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene secretory carrier membrane protein 4 Neighboring gene microRNA 6912 Neighboring gene predicted gene, 31298 Neighboring gene BTB domain containing 2 Neighboring gene predicted gene, 51810 Neighboring gene STARR-positive B cell enhancer ABC_E3899 Neighboring gene MAP kinase-interacting serine/threonine kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
casein kinase I isoform gamma-2; casein kinase I
Names
CKI-gamma 2
NP_001153063.1
NP_598763.1
XP_006513074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159591.1NP_001153063.1  casein kinase I isoform gamma-2 isoform 2

    See identical proteins and their annotated locations for NP_001153063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon and lacks an in-frame internal segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK132871, AK152413, CF612914
    Consensus CDS
    CCDS48638.1
    UniProtKB/Swiss-Prot
    Q8BVP5
    Related
    ENSMUSP00000082560.6, ENSMUST00000085435.7
    Conserved Domains (2) summary
    cd14126
    Location:45332
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:332374
    CK1gamma_C; Casein kinase 1 gamma C terminal
  2. NM_134002.2NP_598763.1  casein kinase I isoform gamma-2 isoform 1

    See identical proteins and their annotated locations for NP_598763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC152410, AK077076, AK132871, AK152413, CF612914
    Consensus CDS
    CCDS24029.1
    UniProtKB/TrEMBL
    Q99K78
    Related
    ENSMUSP00000078706.7, ENSMUST00000079773.14
    Conserved Domains (3) summary
    COG0515
    Location:45356
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14126
    Location:45359
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:359401
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80458465..80476605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513011.3XP_006513074.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_006513074.1

    UniProtKB/Swiss-Prot
    Q8BVP5
    Conserved Domains (2) summary
    cd14126
    Location:45332
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:332374
    CK1gamma_C; Casein kinase 1 gamma C terminal

RNA

  1. XR_001779401.2 RNA Sequence

  2. XR_380333.4 RNA Sequence

  3. XR_003948572.2 RNA Sequence