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ERVFRD-1 endogenous retrovirus group FRD member 1, envelope [ Chlorocebus sabaeus (green monkey) ]

Gene ID: 103222167, updated on 11-Mar-2024

Summary

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Gene symbol
ERVFRD-1
Gene description
endogenous retrovirus group FRD member 1, envelope
See related
Ensembl:ENSCSAG00000019109
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Chlorocebus sabaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus
Summary
Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]
Orthologs
human all
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Genomic context

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Location:
chromosome: Un
Exon count:
2
Annotation release Status Assembly Chr Location
102 current Vero_WHO_p1.0 (GCF_015252025.1) Unplaced Scaffold NW_023666044.1 (11133315..11142617, complement)
100 previous assembly Chlorocebus_sabeus 1.1 (GCF_000409795.2) 17 NC_023658.1 (61033479..61042781)

NW_023666044.1Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 2 Neighboring gene small nucleolar RNA U13 Neighboring gene small integral membrane protein 13 Neighboring gene neural precursor cell expressed, developmentally down-regulated 9 Neighboring gene uncharacterized LOC103222165 Neighboring gene uncharacterized LOC119626789

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Blaise S, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14557543, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in syncytium formation by plasma membrane fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
syncytin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305098.1 → NP_001292027.1  syncytin-2 precursor

    Status: REVIEWED

    Source sequence(s)
    AQIB01159352
    UniProtKB/TrEMBL
    A0A0D9SCN0
    Conserved Domains (1) summary
    cd09851
    Location:380 → 456
    HTLV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of human T-cell leukemia virus type 1 (HTLV-1), and related domains

RefSeqs of Annotated Genomes: Chlorocebus sabaeus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Vero_WHO_p1.0

Genomic

  1. NW_023666044.1 Reference Vero_WHO_p1.0

    Range
    11133315..11142617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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