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Fig4 FIG4 phosphoinositide 5-phosphatase [ Mus musculus (house mouse) ]

Gene ID: 103199, updated on 14-Feb-2023


Official Symbol
Fig4provided by MGI
Official Full Name
FIG4 phosphoinositide 5-phosphataseprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000038417 AllianceGenome:MGI:2143585
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sac3; A530089I17Rik
Predicted to enable phosphatidylinositol bisphosphate phosphatase activity; phosphatidylinositol-3-phosphatase activity; and phosphatidylinositol-4-phosphate phosphatase activity. Acts upstream of or within several processes, including negative regulation of myelination; nervous system development; and phosphatidylinositol metabolic process. Predicted to be located in endosome membrane and lipid droplet. Predicted to colocalize with Golgi apparatus; endoplasmic reticulum; and recycling endosome. Is expressed in cerebral cortex; ganglia; nucleus pulposus; thymus primordium; and vibrissa. Used to study Charcot-Marie-Tooth disease type 4J and Yunis-Varon syndrome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in heart adult (RPKM 7.1), CNS E18 (RPKM 6.7) and 28 other tissues See more
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Genomic context

See Fig4 in Genome Data Viewer
10; 10 B1
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41064168..41179237, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41188172..41303241, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32338 Neighboring gene predicted gene, 32411 Neighboring gene predicted gene, 25526 Neighboring gene adenylate kinase 9 Neighboring gene sperm specific antigen 2 pseudogene Neighboring gene ClpB caseinolytic peptidase B homolog pseudogene

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information



Gene Ontology Provided by MGI

Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
located_in endosome IEA
Inferred from Electronic Annotation
more info
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
colocalizes_with recycling endosome ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
polyphosphoinositide phosphatase
FIG4 homolog
SAC domain-containing protein 3
Sac domain-containing inositol phosphatase 3
phosphatidylinositol 3,5-bisphosphate 5-phosphatase
serine-protein phosphatase FIG4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133999.1NP_598760.1  polyphosphoinositide phosphatase

    See identical proteins and their annotated locations for NP_598760.1

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    Q6A092, Q91WF7
    ENSMUSP00000039598.4, ENSMUST00000043814.5
    Conserved Domains (2) summary
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    Syja_N; SacI homology domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000076.7 Reference GRCm39 C57BL/6J

    41064168..41179237 complement
    GenBank, FASTA, Sequence Viewer (Graphics)