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TNIP1 TNFAIP3 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 10318, updated on 6-Aug-2019

Summary

Official Symbol
TNIP1provided by HGNC
Official Full Name
TNFAIP3 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:16903
See related
Ensembl:ENSG00000145901 MIM:607714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VAN; NAF1; ABIN-1; nip40-1
Summary
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in fat (RPKM 55.9), spleen (RPKM 36.4) and 25 other tissues See more
Orthologs

Genomic context

See TNIP1 in Genome Data Viewer
Location:
5q33.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (151029943..151087685, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150409504..150467221, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378228 Neighboring gene glutathione peroxidase 3 Neighboring gene annexin A6 Neighboring gene uncharacterized LOC107986463

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
NHGRI GWA Catalog
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
NHGRI GWA Catalog
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
NHGRI GWA Catalog
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Nef-associated factor 1 (Naf1) binds to HIV-1 Nef through amino acids 94-412 of Naf1; overexpression of Naf1 in 293T cells increases CD4 expression, and Nef suppresses this activity of Naf1 to downregulate CD4 PubMed
matrix gag VAN is efficiently incorporated into HIV-1 virions, presumably as a result of binding to HIV-1 Matrix PubMed
gag The C-terminus (amino acids 468-637) of virion-associated matrix-interacting protein (VAN) binds to HIV-1 Matrix and has been proposed to play a role in the nuclear import of the HIV-1 preintegration complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
    Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
    Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
glycoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication TAS
Traceable Author Statement
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
TNFAIP3-interacting protein 1
Names
A20-binding inhibitor of NF-kappa-B activation 1
HIV-1 Nef-interacting protein
Nef-associated factor 1 SNP
virion-associated nuclear shuttling protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030590.1 RefSeqGene

    Range
    5001..62718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252385.1NP_001239314.1  TNFAIP3-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001239314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AB252973, AK074400, AK303573, AW589284, DC374977
    Consensus CDS
    CCDS75359.1
    UniProtKB/Swiss-Prot
    Q15025
    UniProtKB/TrEMBL
    A0A0A0MRZ4, B7Z8K2
    Related
    ENSP00000374029.3, ENST00000389378.6
    Conserved Domains (5) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298399
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001252386.2NP_001239315.1  TNFAIP3-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001239315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the coding region, compared to variant 1, one of which is the use of a downstream start codon. Isoform 2 has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB252975, AK074400, AW589284, BX640647
    Consensus CDS
    CCDS58982.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000429891.1, ENST00000520931.5
    Conserved Domains (4) summary
    cd16269
    Location:314326
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:399447
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:161198
    MreC; rod shape-determining protein MreC
    cl20817
    Location:245346
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_001252390.2NP_001239319.1  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001239319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252970, AC008641, AK074400, AK290999, AW589284
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    Q15025
    UniProtKB/TrEMBL
    A8K4N4
    Related
    ENSP00000428187.1, ENST00000522226.5
    Conserved Domains (2) summary
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298538
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001252391.2NP_001239320.1  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001239320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252970, AK074400, AW589284, DA643531
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000317891.7, ENST00000315050.11
    Conserved Domains (2) summary
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298538
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001252392.2NP_001239321.1  TNFAIP3-interacting protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001239321.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting isoform (4) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 4).
    Source sequence(s)
    AB252971, AK074400, AW589284, DA643531
    Consensus CDS
    CCDS58985.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000428243.1, ENST00000523338.5
    Conserved Domains (6) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    pfam15619
    Location:334507
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cd16269
    Location:367379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298399
    GBP_C; Guanylate-binding protein, C-terminal domain
  6. NM_001252393.2NP_001239322.1  TNFAIP3-interacting protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001239322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting isoform (4) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 4).
    Source sequence(s)
    AB252973, AK074400, AW589284
    Consensus CDS
    CCDS58985.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000430971.1, ENST00000518977.5
    Conserved Domains (6) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    pfam15619
    Location:334507
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cd16269
    Location:367379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298399
    GBP_C; Guanylate-binding protein, C-terminal domain
  7. NM_001258454.2NP_001245383.1  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001245383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AC008641
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    Q15025
    Conserved Domains (2) summary
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298538
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001258455.1NP_001245384.1  TNFAIP3-interacting protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001245384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an exon and uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 5) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB177543, AC008641
    Consensus CDS
    CCDS58984.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000431105.1, ENST00000523200.5
    Conserved Domains (3) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298529
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001258456.1NP_001245385.1  TNFAIP3-interacting protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks two exons in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB177544, AC008641
    Consensus CDS
    CCDS58983.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000429912.1, ENST00000524280.5
    Conserved Domains (6) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367379
    GBP_C; coiled coil [structural motif]
    cl02415
    Location:323365
    DUF922; Bacterial protein of unknown function (DUF922)
    cl15254
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298399
    GBP_C; Guanylate-binding protein, C-terminal domain
  10. NM_001364486.2NP_001351415.1  TNFAIP3-interacting protein 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' and 3' UTRs and coding sequence and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (7) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008641
    Conserved Domains (2) summary
    cl19252
    Location:161198
    MreC; rod shape-determining protein MreC
    cl25732
    Location:245485
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001364487.2NP_001351416.1  TNFAIP3-interacting protein 1 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 1. The resulting isoform (8) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008641
    Related
    ENSP00000483944.1, ENST00000610535.5
    Conserved Domains (3) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298529
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_006058.5NP_006049.3  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_006049.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct Cz-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252972, AK074400, AW589284
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000430760.1, ENST00000521591.5
    Conserved Domains (2) summary
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298538
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    151029943..151087685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268355.2XP_005268412.1  TNFAIP3-interacting protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005268412.1

    UniProtKB/TrEMBL
    A0A0A0MRZ4
    Conserved Domains (5) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298399
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. XM_006714752.3XP_006714815.1  TNFAIP3-interacting protein 1 isoform X7

    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000427854.1, ENST00000519339.5
    Conserved Domains (5) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298399
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. XM_017008946.2XP_016864435.1  TNFAIP3-interacting protein 1 isoform X1

  4. XM_017008947.2XP_016864436.1  TNFAIP3-interacting protein 1 isoform X1

  5. XM_017008949.2XP_016864438.1  TNFAIP3-interacting protein 1 isoform X3

  6. XM_017008948.2XP_016864437.1  TNFAIP3-interacting protein 1 isoform X2

  7. XM_017008945.2XP_016864434.1  TNFAIP3-interacting protein 1 isoform X1

  8. XM_017008950.2XP_016864439.1  TNFAIP3-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRZ4
    Conserved Domains (5) summary
    pfam15058
    Location:14149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298399
    GBP_C; Guanylate-binding protein, C-terminal domain
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