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B3GALT5 beta-1,3-galactosyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 10317, updated on 7-Jun-2020

Summary

Official Symbol
B3GALT5provided by HGNC
Official Full Name
beta-1,3-galactosyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:920
See related
Ensembl:ENSG00000183778 MIM:604066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B3T5; GLCT5; B3GalTx; B3GalT-V; beta3Gal-T5; beta-3-Gx-T5; beta-1,3-GalTase 5
Summary
This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]
Expression
Biased expression in small intestine (RPKM 5.1), colon (RPKM 4.2) and 3 other tissues See more
Orthologs

Genomic context

See B3GALT5 in Genome Data Viewer
Location:
21q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (39612940..39673137)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40928369..41034816)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene JCAD pseudogene 1 Neighboring gene B3GALT5 antisense RNA 1 Neighboring gene B3GALT5 ERV-L LTR promoter Neighboring gene immunoglobulin superfamily member 5 Neighboring gene uncharacterized LOC107985499 Neighboring gene uncharacterized LOC107985500

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity, transferring hexosyl groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
poly-N-acetyllactosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus HDA PubMed 
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-1,3-galactosyltransferase 5
Names
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
homolog of C. elegans Bt toxin resistance gene bre-5
NP_001265579.1
NP_001343265.1
NP_001343267.1
NP_001343268.1
NP_006048.1
NP_149360.1
NP_149361.1
NP_149362.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278650.1NP_001265579.1  beta-1,3-galactosyltransferase 5 isoform a

    See identical proteins and their annotated locations for NP_001265579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of the alternate A promoter and contains an alternate 5' UTR compared to variant 1.
    Source sequence(s)
    AB020337, AK292951, AW136254
    Consensus CDS
    CCDS13667.1
    UniProtKB/Swiss-Prot
    Q9Y2C3
    Related
    ENSP00000480285.1, ENST00000615480.4
    Conserved Domains (1) summary
    cl21608
    Location:71261
    Galactosyl_T; Galactosyltransferase
  2. NM_001356336.2NP_001343265.1  beta-1,3-galactosyltransferase 5 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents use of the alternate A promoter and contains an alternate 5' UTR compared to variant 1.
    Source sequence(s)
    AB020337, AF064860, AK292951, AW136254, DQ645732, KF457302
    Consensus CDS
    CCDS13667.1
    Conserved Domains (1) summary
    cl21608
    Location:71261
    Galactosyl_T; Galactosyltransferase
  3. NM_001356338.2NP_001343267.1  beta-1,3-galactosyltransferase 5 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) represents use of the alternate C promoter and contains an alternate 5' UTR compared to variant 1.
    Source sequence(s)
    AB020337, AF064860, AW136254, DQ645737, KF457302
    Consensus CDS
    CCDS13667.1
    Related
    ENSP00000369994.3, ENST00000380620.8
    Conserved Domains (1) summary
    cl21608
    Location:71261
    Galactosyl_T; Galactosyltransferase
  4. NM_001356339.2NP_001343268.1  beta-1,3-galactosyltransferase 5 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents use of the alternate C promoter and contains an alternate 5' UTR compared to variant 1.
    Source sequence(s)
    AB020337, AF064860, AW136254, DQ645738, KF457302
    Consensus CDS
    CCDS13667.1
    Conserved Domains (1) summary
    cl21608
    Location:71261
    Galactosyl_T; Galactosyltransferase
  5. NM_006057.3NP_006048.1  beta-1,3-galactosyltransferase 5 isoform a

    See identical proteins and their annotated locations for NP_006048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents use of a promoter derived from long terminal repeat (LTR) and encodes isoform a.
    Source sequence(s)
    AB020337, AF064860, AW136254, KF457302
    Consensus CDS
    CCDS13667.1
    UniProtKB/Swiss-Prot
    Q9Y2C3
    Related
    ENSP00000369992.1, ENST00000380618.5
    Conserved Domains (1) summary
    cl21608
    Location:71261
    Galactosyl_T; Galactosyltransferase
  6. NM_033170.3NP_149360.1  beta-1,3-galactosyltransferase 5 isoform a

    See identical proteins and their annotated locations for NP_149360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of a promoter derived from long terminal repeat (LTR) and uses an alternate splice site in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AB020337, AF064860, AW136254, KF457302
    Consensus CDS
    CCDS13667.1
    UniProtKB/Swiss-Prot
    Q9Y2C3
    Conserved Domains (1) summary
    cl21608
    Location:71261
    Galactosyl_T; Galactosyltransferase
  7. NM_033171.3NP_149361.1  beta-1,3-galactosyltransferase 5 isoform a

    See identical proteins and their annotated locations for NP_149361.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of a promoter derived from long terminal repeat (LTR) and contains an alternate exon in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AB020337, AF064860, AW136254, KF457302
    Consensus CDS
    CCDS13667.1
    UniProtKB/Swiss-Prot
    Q9Y2C3
    Conserved Domains (1) summary
    cl21608
    Location:71261
    Galactosyl_T; Galactosyltransferase
  8. NM_033172.3NP_149362.2  beta-1,3-galactosyltransferase 5 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4)represents use of a promoter derived from long terminal repeat (LTR), but differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus, compared to isoform a.
    Source sequence(s)
    AB020337, AF064860, AW136254, KF457302
    Consensus CDS
    CCDS74795.1
    UniProtKB/Swiss-Prot
    Q9Y2C3
    UniProtKB/TrEMBL
    A0A0A0MS93
    Related
    ENSP00000381699.3, ENST00000398714.3
    Conserved Domains (1) summary
    cl21608
    Location:75265
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    39612940..39673137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033173.1: Suppressed sequence

    Description
    NM_033173.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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