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Rdh9 retinol dehydrogenase 9 [ Mus musculus (house mouse) ]

Gene ID: 103142, updated on 11-Apr-2024

Summary

Official Symbol
Rdh9provided by MGI
Official Full Name
retinol dehydrogenase 9provided by MGI
Primary source
MGI:MGI:2143528
See related
Ensembl:ENSMUSG00000056148 AllianceGenome:MGI:2143528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crad3
Summary
Enables NAD-retinol dehydrogenase activity. Acts upstream of or within 9-cis-retinoic acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of organelle membrane. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 20.2), large intestine adult (RPKM 14.5) and 4 other tissues See more
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Genomic context

See Rdh9 in Genome Data Viewer
Location:
10 D3; 10 75.21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127612274..127628566)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127776405..127792697)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 182 Neighboring gene retinol dehydrogenase 1 (all trans) Neighboring gene STARR-seq mESC enhancer starr_28237 Neighboring gene retinol dehydrogenase 16 Neighboring gene STARR-seq mESC enhancer starr_28238 Neighboring gene STARR-seq mESC enhancer starr_28239 Neighboring gene STARR-seq mESC enhancer starr_28240 Neighboring gene retinol dehydrogenase 18, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retinol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
retinol dehydrogenase 9
Names
cis-retinol/androgen dehydrogenase type 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153133.2NP_694773.1  retinol dehydrogenase 9 precursor

    See identical proteins and their annotated locations for NP_694773.1

    Status: VALIDATED

    Source sequence(s)
    AC129576, AC131690
    Consensus CDS
    CCDS24251.1
    UniProtKB/TrEMBL
    E9Q9P8, Q8K5C8
    Related
    ENSMUSP00000057732.7, ENSMUST00000052652.7
    Conserved Domains (2) summary
    cd09805
    Location:30306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:30218
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127612274..127628566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)