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ERBB2 erb-b2 receptor tyrosine kinase 2 [ Lipotes vexillifer (Yangtze River dolphin) ]

Gene ID: 103075672, updated on 11-Apr-2024

Summary

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Gene symbol
ERBB2
Gene description
erb-b2 receptor tyrosine kinase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Lipotes vexillifer
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Lipotidae; Lipotes
Orthologs
human mouse all
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Genomic context

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See ERBB2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
28
Annotation release Status Assembly Chr Location
100 current Lipotes_vexillifer_v1 (GCF_000442215.1) Unplaced Scaffold NW_006791954.1 (4277646..4300151)

NW_006791954.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103071875 Neighboring gene post-GPI attachment to proteins phospholipase 3 Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006791954 unplaced scaffold reference Lipotes_vexillifer_v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor tyrosine-protein kinase erbB-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Lipotes vexillifer Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Lipotes_vexillifer_v1 Primary Assembly

Genomic

  1. NW_006791954.1 Reference Lipotes_vexillifer_v1 Primary Assembly

    Range
    4277646..4300151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007465169.1 → XP_007465231.1  receptor tyrosine-protein kinase erbB-2

    UniProtKB/TrEMBL
    A0A340XV51
    Conserved Domains (8) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    smart00261
    Location:557 → 603
    FU; Furin-like repeats
    cd00064
    Location:235 → 280
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:712 → 990
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:720 → 976
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
Nucleotide Protein
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