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SNAPC5 small nuclear RNA activating complex polypeptide 5 [ Homo sapiens (human) ]

Gene ID: 10302, updated on 8-Jul-2021

Summary

Official Symbol
SNAPC5provided by HGNC
Official Full Name
small nuclear RNA activating complex polypeptide 5provided by HGNC
Primary source
HGNC:HGNC:15484
See related
Ensembl:ENSG00000174446 MIM:605979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNAP19
Summary
This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in brain (RPKM 30.5), fat (RPKM 21.0) and 25 other tissues See more
Orthologs
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Genomic context

See SNAPC5 in Genome Data Viewer
Location:
15q22.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (66489748..66497762, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66782086..66790100, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene ATP synthase membrane subunit f pseudogene 6 Neighboring gene ribosomal protein L35a pseudogene 32 Neighboring gene microRNA 4512 Neighboring gene small nucleolar RNA, C/D box 18C Neighboring gene small nucleolar RNA, C/D box 18B Neighboring gene ribosomal protein L4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
snRNA-activating protein complex subunit 5
Names
SNAPc 19 kDa subunit
SNAPc subunit 5
snRNA-activating protein complex 19 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051234.1 RefSeqGene

    Range
    5054..13068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329613.2NP_001316542.1  snRNA-activating protein complex subunit 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in its 5' coding region and differs in the 3' UTR compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC116913, AK024763, BC014315
    Consensus CDS
    CCDS86469.1
    UniProtKB/Swiss-Prot
    O75971
    Related
    ENSP00000308439.7, ENST00000307979.7
    Conserved Domains (1) summary
    pfam15497
    Location:850
    SNAPc19; snRNA-activating protein complex subunit 19, SNAPc subunit 19
  2. NM_001329614.2NP_001316543.1  snRNA-activating protein complex subunit 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC116913, AK024763
  3. NM_001329615.2NP_001316544.1  snRNA-activating protein complex subunit 5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 1. Both variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC116913, AK024763, BG764762
    Consensus CDS
    CCDS10217.1
    UniProtKB/Swiss-Prot
    O75971
    UniProtKB/TrEMBL
    A0A024R5X1
    Related
    ENSP00000319597.5, ENST00000316634.6
    Conserved Domains (1) summary
    pfam15497
    Location:880
    SNAPc19; snRNA-activating protein complex subunit 19, SNAPc subunit 19
  4. NM_006049.4NP_006040.1  snRNA-activating protein complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_006040.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    BU679510, CN347010, DB037177, HY005747
    Consensus CDS
    CCDS10217.1
    UniProtKB/Swiss-Prot
    O75971
    UniProtKB/TrEMBL
    A0A024R5X1
    Related
    ENSP00000457892.1, ENST00000563480.6
    Conserved Domains (1) summary
    pfam15497
    Location:880
    SNAPc19; snRNA-activating protein complex subunit 19, SNAPc subunit 19

RNA

  1. NR_138061.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC066984, BP211241, BU679510, HY005747

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    66489748..66497762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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