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KATNB1 katanin regulatory subunit B1 [ Homo sapiens (human) ]

Gene ID: 10300, updated on 11-Sep-2019

Summary

Official Symbol
KATNB1provided by HGNC
Official Full Name
katanin regulatory subunit B1provided by HGNC
Primary source
HGNC:HGNC:6217
See related
Ensembl:ENSG00000140854 MIM:602703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAT; LIS6
Summary
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 14.6), brain (RPKM 7.5) and 24 other tissues See more
Orthologs

Genomic context

See KATNB1 in Genome Data Viewer
Location:
16q21
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (57735770..57757244)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57769623..57791162)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 7 Neighboring gene mitochondrial carrier 2 pseudogene Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942 Neighboring gene Sharpr-MPRA regulatory region 7405 Neighboring gene kinesin family member C3 Neighboring gene microRNA 6772 Neighboring gene uncharacterized LOC388282

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynein complex binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to microtubule-severing ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to microtubule-severing ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule severing IEA
Inferred from Electronic Annotation
more info
 
mitotic chromosome movement towards spindle pole IEA
Inferred from Electronic Annotation
more info
 
negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
protein targeting NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
katanin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
katanin complex IDA
Inferred from Direct Assay
more info
PubMed 
katanin complex TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
katanin p80 WD40 repeat-containing subunit B1
Names
katanin (80 kDa)
katanin p80 (WD repeat containing) subunit B 1
katanin p80 (WD40-containing) subunit B 1
katanin p80 WD40-containing subunit B1
katanin p80 subunit B1
p80 katanin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046947.1 RefSeqGene

    Range
    5051..26525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005886.3NP_005877.2  katanin p80 WD40 repeat-containing subunit B1

    See identical proteins and their annotated locations for NP_005877.2

    Status: REVIEWED

    Source sequence(s)
    AF052432, BC001353, BU501165
    Consensus CDS
    CCDS10788.1
    UniProtKB/Swiss-Prot
    Q9BVA0
    Related
    ENSP00000368982.3, ENST00000379661.8
    Conserved Domains (4) summary
    cd00200
    Location:7257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67103
    7WD40; WD40 repeat [structural motif]
    pfam13925
    Location:497648
    Katanin_con80; con80 domain of Katanin
    cl26386
    Location:386494
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    57735770..57757244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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