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RGS19 regulator of G protein signaling 19 [ Homo sapiens (human) ]

Gene ID: 10287, updated on 9-Jun-2019

Summary

Official Symbol
RGS19provided by HGNC
Official Full Name
regulator of G protein signaling 19provided by HGNC
Primary source
HGNC:HGNC:13735
See related
Ensembl:ENSG00000171700 MIM:605071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAIP; RGSGAIP
Summary
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues See more
Orthologs

Genomic context

See RGS19 in Genome Data Viewer
Location:
20q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (64073181..64080004, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62704534..62711356, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromosome 20 open reading frame 204 Neighboring gene transcription elongation factor A2 Neighboring gene SOX18 promoter region Neighboring gene SRY-box 18 Neighboring gene microRNA 6813 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1 Neighboring gene neuropeptides B and W receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (z) signalling events, organism-specific biosystemThe heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
brush border IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 19
Names
G alpha interacting protein
G protein signalling regulator 19
guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
regulator of G-protein signalling 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039467.2NP_001034556.1  regulator of G-protein signaling 19

    See identical proteins and their annotated locations for NP_001034556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
    Source sequence(s)
    BC001318, BM554550
    Consensus CDS
    CCDS13555.1
    UniProtKB/Swiss-Prot
    P49795
    Related
    ENSP00000333194.5, ENST00000332298.9
    Conserved Domains (1) summary
    cd08745
    Location:87204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  2. NM_005873.3NP_005864.1  regulator of G-protein signaling 19

    See identical proteins and their annotated locations for NP_005864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript.
    Source sequence(s)
    AF285097, AL590548, BC063010
    Consensus CDS
    CCDS13555.1
    UniProtKB/Swiss-Prot
    P49795
    Related
    ENSP00000378483.1, ENST00000395042.2
    Conserved Domains (1) summary
    cd08745
    Location:87204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    64073181..64080004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260183.2XP_005260240.1  regulator of G-protein signaling 19 isoform X3

    See identical proteins and their annotated locations for XP_005260240.1

    UniProtKB/TrEMBL
    B4DP94
    Conserved Domains (1) summary
    cd08745
    Location:65182
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  2. XM_005260182.3XP_005260239.1  regulator of G-protein signaling 19 isoform X3

    See identical proteins and their annotated locations for XP_005260239.1

    UniProtKB/TrEMBL
    B4DP94
    Conserved Domains (1) summary
    cd08745
    Location:65182
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  3. XM_011528485.2XP_011526787.1  regulator of G-protein signaling 19 isoform X2

    See identical proteins and their annotated locations for XP_011526787.1

    UniProtKB/Swiss-Prot
    P49795
    Conserved Domains (1) summary
    cd08745
    Location:87204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  4. XM_011528484.2XP_011526786.1  regulator of G-protein signaling 19 isoform X1

    Conserved Domains (1) summary
    cd08745
    Location:116233
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  5. XM_011528486.2XP_011526788.1  regulator of G-protein signaling 19 isoform X2

    See identical proteins and their annotated locations for XP_011526788.1

    UniProtKB/Swiss-Prot
    P49795
    Conserved Domains (1) summary
    cd08745
    Location:87204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
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