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RGS19 regulator of G protein signaling 19 [ Homo sapiens (human) ]

Gene ID: 10287, updated on 21-Dec-2019

Summary

Official Symbol
RGS19provided by HGNC
Official Full Name
regulator of G protein signaling 19provided by HGNC
Primary source
HGNC:HGNC:13735
See related
Ensembl:ENSG00000171700 MIM:605071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAIP; RGSGAIP
Summary
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues See more
Orthologs

Genomic context

See RGS19 in Genome Data Viewer
Location:
20q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (64073181..64080004, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62704534..62711356, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromosome 20 open reading frame 204 Neighboring gene transcription elongation factor A2 Neighboring gene SOX18 promoter region Neighboring gene SRY-box transcription factor 18 Neighboring gene microRNA 6813 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1 Neighboring gene neuropeptides B and W receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
brush border IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 19
Names
G alpha interacting protein
G protein signalling regulator 19
guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
regulator of G-protein signalling 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039467.2NP_001034556.1  regulator of G-protein signaling 19

    See identical proteins and their annotated locations for NP_001034556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
    Source sequence(s)
    BC001318, BM554550
    Consensus CDS
    CCDS13555.1
    UniProtKB/Swiss-Prot
    P49795
    Related
    ENSP00000333194.5, ENST00000332298.9
    Conserved Domains (1) summary
    cd08745
    Location:87204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  2. NM_005873.3NP_005864.1  regulator of G-protein signaling 19

    See identical proteins and their annotated locations for NP_005864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript.
    Source sequence(s)
    AF285097, AL590548, BC063010
    Consensus CDS
    CCDS13555.1
    UniProtKB/Swiss-Prot
    P49795
    Related
    ENSP00000378483.1, ENST00000395042.2
    Conserved Domains (1) summary
    cd08745
    Location:87204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    64073181..64080004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260183.2XP_005260240.1  regulator of G-protein signaling 19 isoform X3

    See identical proteins and their annotated locations for XP_005260240.1

    UniProtKB/TrEMBL
    B4DP94
    Conserved Domains (1) summary
    cd08745
    Location:65182
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  2. XM_005260182.3XP_005260239.1  regulator of G-protein signaling 19 isoform X3

    See identical proteins and their annotated locations for XP_005260239.1

    UniProtKB/TrEMBL
    B4DP94
    Conserved Domains (1) summary
    cd08745
    Location:65182
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  3. XM_011528485.2XP_011526787.1  regulator of G-protein signaling 19 isoform X2

    See identical proteins and their annotated locations for XP_011526787.1

    UniProtKB/Swiss-Prot
    P49795
    Conserved Domains (1) summary
    cd08745
    Location:87204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  4. XM_011528484.2XP_011526786.1  regulator of G-protein signaling 19 isoform X1

    Conserved Domains (1) summary
    cd08745
    Location:116233
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
  5. XM_011528486.2XP_011526788.1  regulator of G-protein signaling 19 isoform X2

    See identical proteins and their annotated locations for XP_011526788.1

    UniProtKB/Swiss-Prot
    P49795
    Conserved Domains (1) summary
    cd08745
    Location:87204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
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