Tcta T cell leukemia translocation altered gene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tctaprovided by MGI
Official Full Name: T cell leukemia translocation altered geneprovided by MGI
Primary source: MGI:MGI:1918829
See related: Ensembl:ENSMUSG00000039461 AllianceGenome:MGI:1918829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tctal; 9130410M22Rik
Summary: Predicted to be involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in cranial ganglion; dorsal root ganglion; sensory organ; and trigeminal nerve. Orthologous to human TCTA (T cell leukemia translocation altered). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 28.4), genital fat pad adult (RPKM 27.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.2 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108180154..108183358, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108302955..108306159, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW553637 (e-PCR)
- UniSTS:179977

RH127115 (e-PCR)
- UniSTS:208449

Homology

Homologs of the Tcta gene: The Tcta gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 431 organisms have orthologs with human gene Tcta
Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast fusion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in osteoclast fusion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-cell leukemia translocation-altered gene protein homolog

Names: T-cell leukemia translocation altered

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311156.2 → NP_001298085.1 T-cell leukemia translocation-altered gene protein homolog isoform 2

See identical proteins and their annotated locations for NP_001298085.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC161260

Consensus CDS

CCDS81073.1

UniProtKB/TrEMBL

A0A0A6YXI4, A0A6P5QHH0

Related

ENSMUSP00000142002.2, ENSMUST00000192886.6

Conserved Domains (1) summary

pfam15128
Location:15 → 106

T_cell_tran_alt; T-cell leukemia translocation-altered
NM_133986.3 → NP_598747.1 T-cell leukemia translocation-altered gene protein homolog isoform 1

See identical proteins and their annotated locations for NP_598747.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC161260

Consensus CDS

CCDS23520.1

UniProtKB/Swiss-Prot

Q8VEA7

Related

ENSMUSP00000045063.8, ENSMUST00000044725.9

Conserved Domains (1) summary

pfam15128
Location:15 → 122

T_cell_tran_alt; T-cell leukemia translocation-altered