Format

Send to:

Choose Destination

PRSS16 serine protease 16 [ Homo sapiens (human) ]

Gene ID: 10279, updated on 1-Jun-2020

Summary

Official Symbol
PRSS16provided by HGNC
Official Full Name
serine protease 16provided by HGNC
Primary source
HGNC:HGNC:9480
See related
Ensembl:ENSG00000112812 MIM:607169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSSP
Summary
This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 6.8), stomach (RPKM 3.4) and 17 other tissues See more
Orthologs

Genomic context

See PRSS16 in Genome Data Viewer
Location:
6p22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27247701..27256620)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27215480..27224399)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tRNA-Val (anticodon AAC) 5-1 Neighboring gene tRNA-Ile (anticodon AAT) 5-3 Neighboring gene cell division cycle associated 7 pseudogene Neighboring gene tRNA-Ile (anticodon AAT) 9-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants conferring risk of schizophrenia.
NHGRI GWA Catalog
Common variants on chromosome 6p22.1 are associated with schizophrenia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36271, FLJ40714, FLJ44172

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type peptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thymus-specific serine protease
Names
protease, serine 16
protease, serine, 16 (thymus)
thymus specific serine peptidase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005865.4NP_005856.1  thymus-specific serine protease

    See identical proteins and their annotated locations for NP_005856.1

    Status: REVIEWED

    Source sequence(s)
    AF052514, AK093590, AK314037, AL021808, BG119060
    Consensus CDS
    CCDS4623.1
    UniProtKB/Swiss-Prot
    Q9NQE7
    Related
    ENSP00000230582.3, ENST00000230582.8
    Conserved Domains (1) summary
    pfam05577
    Location:64494
    Peptidase_S28; Serine carboxypeptidase S28

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    27247701..27256620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010165.1XP_016865654.1  thymus-specific serine protease isoform X5

    UniProtKB/TrEMBL
    F2Z2N5
    Related
    ENSP00000404349.2, ENST00000421826.6
  2. XM_017010162.2XP_016865651.1  thymus-specific serine protease isoform X2

  3. XM_017010164.2XP_016865653.1  thymus-specific serine protease isoform X4

  4. XM_017010163.2XP_016865652.1  thymus-specific serine protease isoform X3

  5. XM_017010161.2XP_016865650.1  thymus-specific serine protease isoform X1

Support Center