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STAG1 stromal antigen 1 [ Homo sapiens (human) ]

Gene ID: 10274, updated on 29-Mar-2020

Summary

Official Symbol
STAG1provided by HGNC
Official Full Name
stromal antigen 1provided by HGNC
Primary source
HGNC:HGNC:11354
See related
Ensembl:ENSG00000118007 MIM:604358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SA1; MRD47; SCC3A
Summary
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 10.7), endometrium (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See STAG1 in Genome Data Viewer
Location:
3q22.3
Exon count:
39
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (136336235..136752412, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136055077..136471245, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3094 Neighboring gene propionyl-CoA carboxylase subunit beta Neighboring gene RNA, U6 small nuclear 1284, pseudogene Neighboring gene RNY4 pseudogene 4 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 10 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 pseudogene Neighboring gene RNA, U6 small nuclear 789, pseudogene Neighboring gene solute carrier family 35 member G2 Neighboring gene NCK1 divergent transcript Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene NCK adaptor protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
MENTAL RETARDATION, AUTOSOMAL DOMINANT 47
MedGen: C4539951 OMIM: 617635 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781D1416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromosome TAS
Traceable Author Statement
more info
 
chromosome, centromeric region TAS
Traceable Author Statement
more info
 
cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cohesin subunit SA-1
Names
SCC3 homolog 1
nuclear protein stromal antigen 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005862.3NP_005853.2  cohesin subunit SA-1

    See identical proteins and their annotated locations for NP_005853.2

    Status: REVIEWED

    Source sequence(s)
    AC069524, BC017735, BC064699
    Consensus CDS
    CCDS3090.1
    UniProtKB/Swiss-Prot
    Q8WVM7
    UniProtKB/TrEMBL
    Q4LE48
    Related
    ENSP00000372689.2, ENST00000383202.7
    Conserved Domains (2) summary
    pfam08514
    Location:160268
    STAG; STAG domain
    pfam14621
    Location:358
    RFX5_DNA_bdg; RFX5 DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    136336235..136752412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005525.1XP_016861014.1  cohesin subunit SA-1 isoform X3

  2. XM_017005524.2XP_016861013.1  cohesin subunit SA-1 isoform X2

    Related
    ENSP00000404396.2, ENST00000434713.6
    Conserved Domains (1) summary
    cl26728
    Location:26172
    STAG; STAG domain
  3. XM_011512331.2XP_011510633.1  cohesin subunit SA-1 isoform X1

    See identical proteins and their annotated locations for XP_011510633.1

    Conserved Domains (1) summary
    pfam08514
    Location:23131
    STAG; STAG domain
  4. XM_017005523.1XP_016861012.1  cohesin subunit SA-1 isoform X1

    Conserved Domains (1) summary
    pfam08514
    Location:23131
    STAG; STAG domain
  5. XM_011512329.2XP_011510631.1  cohesin subunit SA-1 isoform X1

    See identical proteins and their annotated locations for XP_011510631.1

    Conserved Domains (1) summary
    pfam08514
    Location:23131
    STAG; STAG domain

RNA

  1. XR_001739978.1 RNA Sequence

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