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trpc4b transient receptor potential cation channel, subfamily C, member 4b [ Danio rerio (zebrafish) ]

Gene ID: 102725536, updated on 20-Feb-2026
Official Symbol
trpc4bprovided by ZNC
Official Full Name
transient receptor potential cation channel, subfamily C, member 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120329-1
See related
Ensembl:ENSDARG00000102017 AllianceGenome:ZFIN:ZDB-GENE-120329-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
trpc4a
Summary
Enables monoatomic cation channel activity. Acts upstream of or within monoatomic cation transport. Located in plasma membrane. Is expressed in integument; olfactory bulb; and olfactory placode. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See trpc4b in Genome Data Viewer
Location:
chromosome: 15
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 15 NC_133190.1 (35256676..35314487)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 15 NC_007126.7 (32643001..32704081)

Chromosome 15 - NC_133190.1Genomic Context describing neighboring genes Neighboring gene FRAS1 related extracellular matrix 2b Neighboring gene uncharacterized LOC137487687 Neighboring gene si:dkey-74i1.3 Neighboring gene uncharacterized LOC141377872 Neighboring gene neurobeachin b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Vinayagam D, et al. Elife, 2020 Nov 25. PMID 33236980, Free PMC Article
  2. Electron cryo-microscopy structure of the canonical TRPC4 ion channel. Vinayagam D, et al. Elife, 2018 May 2. PMID 29717981, Free PMC Article
  3. Phylogeny and expression of canonical transient receptor potential (TRPC) genes in developing zebrafish. Von Niederhäusern V, et al. Dev Dyn, 2013 Dec. PMID 24038627
  4. Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish. You MS, et al. J Photochem Photobiol B, 2020 Dec. PMID 33186875
  5. Epidermal keratinocyte polarity and motility require Ca²⁺ influx through TRPV1. Graham DM, et al. J Cell Sci, 2013 Oct 15. PMID 23943873, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
short transient receptor potential channel 4b
Names
transient receptor potential cation channel subfamily c member 4a
trpc4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289881.1 → NP_001276810.1  short transient receptor potential channel 4b

    See identical proteins and their annotated locations for NP_001276810.1

    Status: PROVISIONAL

    Source sequence(s)
    KF446631
    UniProtKB/TrEMBL
    U3N7D8
    Related
    ENSDARP00000155234.1, ENSDART00000189433.1
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 748
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:70 → 98
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133190.1 Reference GRCz12tu Primary Assembly

    Range
    35256676..35314487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291786.5 → XP_009290061.1  short transient receptor potential channel 4b isoform X1

    UniProtKB/TrEMBL
    A0A0R4IM91, A0A8M3AIN4
    Related
    ENSDARP00000136413.1
    Conserved Domains (4) summary
    cd00204
    Location:39 → 162
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:17 → 748
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:176 → 235
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:70 → 98
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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