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LOC102724652 crystallin alpha A2 [ Homo sapiens (human) ]

Gene ID: 102724652, updated on 23-Nov-2021

Summary

Gene symbol
LOC102724652
Gene description
crystallin alpha A2
See related
Ensembl:ENSG00000276076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRYAA; CRYAA2
Annotation information
Note: GeneID:102724652 is on a scaffold that is thought to be a false duplication and thus this gene is likely redundant with GeneID:1409. [11 Jun 2021]
Expression
Restricted expression toward kidney (RPKM 53.7) See more
Orthologs
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Genomic context

See LOC102724652 in Genome Data Viewer
Location:
21p12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (6499203..6564489)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724701 Neighboring gene uncharacterized CH507-145C22.1 Neighboring gene cystathionine beta-synthase like Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 5 Neighboring gene 39S ribosomal protein L51, mitochondrial pseudogene Neighboring gene FOXM1-regulated, gastric cancer associated-like Neighboring gene carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 pseudogene Neighboring gene uncharacterized LOC105379497

Genomic regions, transcripts, and products

Genomic Sequence:
NC_000021.9 Chromosome 21 Reference GRCh38.p13 Primary Assembly

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC96924

General protein information

Preferred Names
alpha-crystallin A2 chain
Names
alpha-crystallin A chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314050.5NP_001300979.1  alpha-crystallin A2 chain isoform 1

    Status: VALIDATED

    Source sequence(s)
    FP236240
    Consensus CDS
    CCDS82651.1
    UniProtKB/Swiss-Prot
    P02489
    UniProtKB/TrEMBL
    A0A140G945
    Related
    ENSP00000482816.1, ENST00000619537.5
    Conserved Domains (2) summary
    cd06497
    Location:60145
    ACD_alphaA-crystallin_HspB4; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaA-crystallin (HspB4, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:151
    Crystallin; Alpha crystallin A chain, N terminal
  2. NM_001320719.1NP_001307648.1  alpha-crystallin A2 chain isoform 2

    Status: VALIDATED

    Source sequence(s)
    BM671946, BQ640485
    Consensus CDS
    CCDS82652.1
    UniProtKB/TrEMBL
    E9PHE4
    Related
    ENSP00000485302.1, ENST00000624932.1
    Conserved Domains (1) summary
    cl00175
    Location:26108
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    6499203..6564489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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