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TBC1D3E TBC1 domain family member 3E [ Homo sapiens (human) ]

Gene ID: 102723859, updated on 24-Apr-2022

Summary

Official Symbol
TBC1D3Eprovided by HGNC
Official Full Name
TBC1 domain family member 3Eprovided by HGNC
Primary source
HGNC:HGNC:27071
See related
Ensembl:ENSG00000278599 MIM:610808; AllianceGenome:HGNC:27071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRC17; TBC1D3; TBC1D3A; TBC1DE3
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 27.0), skin (RPKM 18.1) and 25 other tissues See more
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Genomic context

See TBC1D3E in Genome Data Viewer
Location:
17q12
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38124106..38138868)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38991015..39001929)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 3C Neighboring gene puromycin-sensitive aminopeptidase-like protein Neighboring gene uncharacterized LOC102723851 Neighboring gene RNA, 5S ribosomal pseudogene 526 Neighboring gene uncharacterized LOC102723933

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Clone Names

  • DKFZp434P2235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TBC1 domain family member 3E
Names
Prostate cancer gene 17 protein
Protein TRE17-alpha
Rab GTPase-activating protein PRC17
TBC1 domain family member 3
TBC1 domain family member-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291466.2NP_001278395.1  TBC1 domain family member 3E

    See identical proteins and their annotated locations for NP_001278395.1

    Status: VALIDATED

    Source sequence(s)
    AC233968
    Consensus CDS
    CCDS77009.1
    UniProtKB/Swiss-Prot
    A0A087X179
    Related
    ENSP00000483965.1, ENST00000621587.2
    Conserved Domains (1) summary
    smart00164
    Location:99312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38124106..38138868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722254.3XP_006722317.1  TBC1 domain family member 3E isoform X1

    See identical proteins and their annotated locations for XP_006722317.1

    UniProtKB/Swiss-Prot
    A0A087X179
    Conserved Domains (1) summary
    smart00164
    Location:99312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2163065..2173980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    38991015..39001929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)